| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
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| Ligand | BDBM50312673 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_615363 (CHEMBL1103300) |
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| IC50 | >4000±n/a nM |
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| Citation |  Uddin, MJ; Smithson, DC; Brown, KM; Crews, BC; Connelly, M; Zhu, F; Marnett, LJ; Guy, RK Podophyllotoxin analogues active versus Trypanosoma brucei. Bioorg Med Chem Lett20:1787-91 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 |
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| Name: | Prostaglandin G/H synthase 2 |
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| Synonyms: | Cox-2 | Cox2 | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2) | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGH2_MOUSE | PGHS-2 | PHS II | Pghs-b | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2 | TIS10 protein | Tis10 |
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| Type: | Protein |
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| Mol. Mass.: | 69020.39 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q05769 |
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| Residue: | 604 |
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| Sequence: | MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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| BDBM50312673 |
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| n/a |
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| Name | BDBM50312673 |
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| Synonyms: | (S)-N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-(6-methoxynaphthalen-2-yl)propanamide | CHEMBL1076643 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H48N2O12 |
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| Mol. Mass. | 796.8581 |
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| SMILES | COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)NCCCCNC(=O)CCC(=O)O[C@H]1[C@@H]2COC(=O)[C@H]2[C@@H](c2cc(OC)c(OC)c(OC)c2)c2cc3OCOc3cc12 |r| |
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| Structure | 
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