| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50312755 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_615646 (CHEMBL1104220) |
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| IC50 | 72±n/a nM |
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| Citation |  Zeng, Q; Bourbeau, MP; Wohlhieter, GE; Yao, G; Monenschein, H; Rider, JT; Lee, MR; Zhang, S; Lofgren, J; Freeman, D; Li, C; Tominey, E; Huang, X; Hoffman, D; Yamane, H; Tasker, AS; Dominguez, C; Viswanadhan, VN; Hungate, R; Zhang, X 2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics. Bioorg Med Chem Lett20:1652-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50312755 |
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| n/a |
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| Name | BDBM50312755 |
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| Synonyms: | (S)-3-(4-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | CHEMBL1080740 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19ClN6S |
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| Mol. Mass. | 398.912 |
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| SMILES | Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(Cl)cc2)s1 |r| |
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| Structure | 
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