Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50313124 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_616579 (CHEMBL1099716) |
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IC50 | 60±n/a nM |
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Citation | Bernotas, RC; Antane, S; Shenoy, R; Le, VD; Chen, P; Harrison, BL; Robichaud, AJ; Zhang, GM; Smith, D; Schechter, LE 3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. Bioorg Med Chem Lett20:1657-60 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50313124 |
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n/a |
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Name | BDBM50313124 |
Synonyms: | 1-(1-methylpyrrolidin-3-yl)-3-(naphthalen-1-ylsulfonyl)-1H-indole | CHEMBL1080381 |
Type | Small organic molecule |
Emp. Form. | C23H22N2O2S |
Mol. Mass. | 390.498 |
SMILES | CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc2ccccc12 |
Structure |
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