| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase |
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| Ligand | BDBM50313225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_616836 (CHEMBL1100220) |
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| IC50 | 3400±n/a nM |
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| Citation |  Wang, J; Limburg, D; Carter, J; Mbalaviele, G; Gierse, J; Vazquez, M Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template. Bioorg Med Chem Lett20:1604-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase |
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| Name: | Prostaglandin E synthase |
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| Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
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| Type: | Protein |
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| Mol. Mass.: | 17112.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 152 |
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| Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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| BDBM50313225 |
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| n/a |
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| Name | BDBM50313225 |
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| Synonyms: | 4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-thiochromene-3-carboxylic acid{2-[2-(3,4-dichloro-phenyl)-ethyl]-phenyl}-amide | CHEMBL1087254 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19Cl2NO4S |
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| Mol. Mass. | 488.383 |
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| SMILES | Clc1ccc(CCc2ccccc2NC(=O)C2CS(=O)(=O)c3ccccc3C2=O)cc1Cl |
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| Structure | 
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