Reaction Details |
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Target | Prostacyclin synthase |
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Ligand | BDBM50313205 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_616845 (CHEMBL1100229) |
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IC50 | >100000±n/a nM |
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Citation | Wang, J; Limburg, D; Carter, J; Mbalaviele, G; Gierse, J; Vazquez, M Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template. Bioorg Med Chem Lett20:1604-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostacyclin synthase |
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Name: | Prostacyclin synthase |
Synonyms: | CYP8 | CYP8A1 | PTGIS | PTGIS_HUMAN | Prostaglandin I2 synthase |
Type: | PROTEIN |
Mol. Mass.: | 57109.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_157785 |
Residue: | 500 |
Sequence: | MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK
HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE
KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL
YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL
LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE
VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF
YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR
YGFGLMQPEHDVPVRYRIRP
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BDBM50313205 |
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n/a |
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Name | BDBM50313205 |
Synonyms: | 4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid(3',4'-dichloro-biphenyl-4-yl)-amide | CHEMBL1087267 |
Type | Small organic molecule |
Emp. Form. | C21H14Cl2N2O4S |
Mol. Mass. | 461.318 |
SMILES | OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1 |t:1| |
Structure |
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