| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lyn |
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| Ligand | BDBM50313569 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_614210 (CHEMBL1105160) |
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| IC50 | 540±n/a nM |
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| Citation |  Boschelli, DH; Subrath, J; Niu, C; Wu, B; Wang, Y; Lee, J; Brennan, A; Ho, M; Deng, B; Yang, X; Xu, X; Leung, L; Wang, J; Atherton, J; Chaudhary, D Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCtheta inhibitors. Bioorg Med Chem Lett20:1965-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lyn |
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| Name: | Tyrosine-protein kinase Lyn |
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| Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
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| Type: | Protein |
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| Mol. Mass.: | 58575.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07948 |
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| Residue: | 512 |
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| Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
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| BDBM50313569 |
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| n/a |
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| Name | BDBM50313569 |
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| Synonyms: | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(2-(6-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)vinyl)nicotinonitrile | CHEMBL1084411 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29N7 |
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| Mol. Mass. | 463.5768 |
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| SMILES | CN1CCN(Cc2cccc(\C=C\c3cncc(C#N)c3Nc3ccc4[nH]ccc4c3C)n2)CC1 |
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| Structure | 
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