Reaction Details |
| Report a problem with these data |
Target | Orexin/Hypocretin receptor type 1 |
---|
Ligand | BDBM50314681 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_625829 (CHEMBL1109765) |
---|
Ki | 0.4±n/a nM |
---|
Citation | Coleman, PJ; Schreier, JD; McGaughey, GB; Bogusky, MJ; Cox, CD; Hartman, GD; Ball, RG; Harrell, CM; Reiss, DR; Prueksaritanont, T; Winrow, CJ; Renger, JJ Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists. Bioorg Med Chem Lett20:2311-5 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Orexin/Hypocretin receptor type 1 |
---|
Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
|
|
|
BDBM50314681 |
---|
n/a |
---|
Name | BDBM50314681 |
Synonyms: | (5-chloro-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-(6-fluoroquinazolin-2-yl)-3,6-diazabicyclo[3.2.1]octan-3-yl)methanone | CHEMBL1093725 |
Type | Small organic molecule |
Emp. Form. | C23H19ClFN7O |
Mol. Mass. | 463.895 |
SMILES | Fc1ccc2nc(ncc2c1)N1CC2CC1CN(C2)C(=O)c1cc(Cl)ccc1-n1nccn1 |
Structure |
|