Reaction Details |
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Target | Sphingosine 1-phosphate receptor 1 |
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Ligand | BDBM50315814 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_626103 (CHEMBL1111629) |
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EC50 | 1.8±n/a nM |
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Citation | Hamada, M; Nakamura, M; Kiuchi, M; Marukawa, K; Tomatsu, A; Shimano, K; Sato, N; Sugahara, K; Asayama, M; Takagi, K; Adachi, K Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate. J Med Chem53:3154-68 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 1 |
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Name: | Sphingosine 1-phosphate receptor 1 |
Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
Type: | Enzyme |
Mol. Mass.: | 42836.02 |
Organism: | Homo sapiens (Human) |
Description: | P21453 |
Residue: | 382 |
Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM50315814 |
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n/a |
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Name | BDBM50315814 |
Synonyms: | 2-Amino-4-[2'-fluoro-4'-(4-methylphenoxy)biphenyl-4-yl]-2-(phosphoryloxymethyl)butanol | CHEMBL1092284 |
Type | Small organic molecule |
Emp. Form. | C24H28NO6P |
Mol. Mass. | 457.456 |
SMILES | Cc1ccc(Oc2ccc(cc2)-c2ccc(CCC(N)(CO)COP(O)(O)=O)cc2)cc1 |
Structure |
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