Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50315961 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_625728 (CHEMBL1103558) |
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IC50 | 310±n/a nM |
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Citation | Tester, R; Tan, X; Luedtke, GR; Nashashibi, I; Schinzel, K; Liang, W; Jung, J; Dugar, S; Liclican, A; Tabora, J; Levy, DE; Do, S Amide-based inhibitors of p38alpha MAP kinase. Part 2: design, synthesis and SAR of potent N-pyrimidyl amides. Bioorg Med Chem Lett20:2560-3 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50315961 |
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n/a |
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Name | BDBM50315961 |
Synonyms: | (S)-N-(4-aminobutyl)-N-(2-(1-hydroxypropan-2-ylamino)pyrimidin-4-yl)-2,3-dihydrobenzofuran-5-carboxamide | CHEMBL1091288 |
Type | Small organic molecule |
Emp. Form. | C20H27N5O3 |
Mol. Mass. | 385.4601 |
SMILES | C[C@@H](CO)Nc1nccc(n1)N(CCCCN)C(=O)c1ccc2OCCc2c1 |r| |
Structure |
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