| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50317126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_630655 (CHEMBL1111089) |
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| EC50 | 571±n/a nM |
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| Citation |  Ye, XY; Chen, S; Zhang, H; Locke, KT; O'Malley, K; Zhang, L; Srivastava, R; Miao, B; Meyers, D; Monshizadegan, H; Search, D; Grimm, D; Zhang, R; Lippy, J; Twamley, C; Muckelbauer, JK; Chang, C; An, Y; Hosagrahara, V; Zhang, L; Yang, TJ; Mukherjee, R; Cheng, PT; Tino, JA Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation. Bioorg Med Chem Lett20:2933-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 57613.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37231 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50317126 |
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| n/a |
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| Name | BDBM50317126 |
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| Synonyms: | (S)-2-((1-(3-((2-(4-chlorophenyl)oxazol-4-yl)methoxy)phenyl)ethyl)(m-tolyloxycarbonyl)amino)acetic acid | CHEMBL1088099 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25ClN2O6 |
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| Mol. Mass. | 520.961 |
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| SMILES | C[C@H](N(CC(O)=O)C(=O)Oc1cccc(C)c1)c1cccc(OCc2coc(n2)-c2ccc(Cl)cc2)c1 |r| |
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| Structure | 
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