Reaction Details |
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Target | Peroxisome proliferator-activated receptor alpha |
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Ligand | BDBM50314814 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_630653 (CHEMBL1111087) |
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EC50 | 8±n/a nM |
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Citation | Ye, XY; Chen, S; Zhang, H; Locke, KT; O'Malley, K; Zhang, L; Srivastava, R; Miao, B; Meyers, D; Monshizadegan, H; Search, D; Grimm, D; Zhang, R; Lippy, J; Twamley, C; Muckelbauer, JK; Chang, C; An, Y; Hosagrahara, V; Zhang, L; Yang, TJ; Mukherjee, R; Cheng, PT; Tino, JA Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation. Bioorg Med Chem Lett20:2933-7 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peroxisome proliferator-activated receptor alpha |
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Name: | Peroxisome proliferator-activated receptor alpha |
Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
Type: | Enzyme |
Mol. Mass.: | 52222.08 |
Organism: | Homo sapiens (Human) |
Description: | Q07869 |
Residue: | 468 |
Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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BDBM50314814 |
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n/a |
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Name | BDBM50314814 |
Synonyms: | 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(p-tolyloxycarbonyl)amino)acetic acid | 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(ptolyloxycarbonyl)amino)acetic acid | CHEMBL1089210 | N-(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)-N-[(4-methylphenoxy)carbonyl]glycine |
Type | Small organic molecule |
Emp. Form. | C28H25ClN2O6 |
Mol. Mass. | 520.961 |
SMILES | Cc1oc(nc1COc1cccc(CN(CC(O)=O)C(=O)Oc2ccc(C)cc2)c1)-c1ccc(Cl)cc1 |
Structure |
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