| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50317130 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_630653 (CHEMBL1111087) |
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| EC50 | 51±n/a nM |
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| Citation |  Ye, XY; Chen, S; Zhang, H; Locke, KT; O'Malley, K; Zhang, L; Srivastava, R; Miao, B; Meyers, D; Monshizadegan, H; Search, D; Grimm, D; Zhang, R; Lippy, J; Twamley, C; Muckelbauer, JK; Chang, C; An, Y; Hosagrahara, V; Zhang, L; Yang, TJ; Mukherjee, R; Cheng, PT; Tino, JA Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation. Bioorg Med Chem Lett20:2933-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50317130 |
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| n/a |
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| Name | BDBM50317130 |
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| Synonyms: | (S)-2-((1-(3-((2-(4-chlorophenyl)oxazol-4-yl)methoxy)phenyl)ethyl)((4-fluoro-3-methoxyphenoxy)carbonyl)amino)acetic acid | CHEMBL1088257 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24ClFN2O7 |
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| Mol. Mass. | 554.951 |
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| SMILES | COc1cc(OC(=O)N(CC(O)=O)[C@@H](C)c2cccc(OCc3coc(n3)-c3ccc(Cl)cc3)c2)ccc1F |r| |
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| Structure | 
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