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TargetRibosyldihydronicotinamide dehydrogenase [quinone]
LigandBDBM50317139
Substrate/Competitorn/a
Meas. Tech.ChEMBL_630842
IC50 31±n/a nM
Citation Nolan KAHumphries MPBryce RAStratford IJ Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett 20:2832-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ribosyldihydronicotinamide dehydrogenase [quinone]
Name:Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:Metallothionein-3 | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:Protein
Mol. Mass.:25917.25
Organism:Homo sapiens (Human)
Description:P16083
Residue:231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL
SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV
LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC
GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
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  Blast E-value cutoff:
BDBM50317139
n/a
NameBDBM50317139
Synonyms:5-(2-(diethylamino)ethylamino)-7-hydroxy-10-methoxy-6H-imidazo[4,5,1-de]acridin-6-one | 5-(2-Diethylamino-ethylamino)-7-hydroxy-10-methoxy-2,10b-diaza-aceanthrylen-6-one | CHEMBL8219 | NSC-660840
TypeSmall organic molecule
Emp. Form.C21H24N4O3
Mol. Mass.380.4403
SMILESCCN(CC)CCNc1ccc2ncn3c2c1c(=O)c1c(O)ccc(OC)c31
Structure
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