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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 2C | ||
| Ligand | BDBM50319425 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_634057 (CHEMBL1118329) | ||
| Ki | >10000±n/a nM | ||
| Citation |  Xiong, Y; Teegarden, BR; Choi, JS; Strah-Pleynet, S; Decaire, M; Jayakumar, H; Dosa, PI; Casper, MD; Pham, L; Feichtinger, K; Ullman, B; Adams, J; Yuskin, D; Frazer, J; Morgan, M; Sadeque, A; Chen, W; Webb, RR; Connolly, DT; Semple, G; Al-Shamma, H Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis. J Med Chem53:4412-21 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 2C | |||
| Name: | 5-hydroxytryptamine receptor 2C | ||
| Synonyms: | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 51836.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28335 | ||
| Residue: | 458 | ||
| Sequence: |
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| BDBM50319425 | |||
| n/a | |||
| Name | BDBM50319425 | ||
| Synonyms: | CHEMBL1084865 | N-{3-(4-Chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(3-oxo-piperazin-1-yl)-ethoxy]-phenyl}-3-trifluoromethyl-benzamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23ClF3N5O3 | ||
| Mol. Mass. | 521.919 | ||
| SMILES | Cn1ncc(Cl)c1-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1OCCN1CCNC(=O)C1 |(-5.14,-22.2,;-4.83,-23.71,;-5.86,-24.85,;-5.09,-26.19,;-3.58,-25.86,;-2.43,-26.89,;-3.42,-24.34,;-2.09,-23.57,;-.75,-24.34,;.58,-23.57,;1.92,-24.34,;3.25,-23.57,;3.25,-22.03,;4.58,-24.33,;4.58,-25.87,;5.91,-26.64,;7.25,-25.87,;7.24,-24.32,;5.9,-23.56,;8.57,-23.54,;9.91,-24.3,;8.56,-22,;9.89,-22.76,;.58,-22.02,;-.76,-21.26,;-2.09,-22.03,;-3.42,-21.26,;-3.42,-19.72,;-4.76,-18.95,;-4.76,-17.41,;-3.42,-16.64,;-3.42,-15.1,;-4.75,-14.33,;-6.09,-15.09,;-7.42,-14.32,;-6.09,-16.64,)| | ||
| Structure | 
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