| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 1 |
|---|
| Ligand | BDBM50319466 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_634206 (CHEMBL1119788) |
|---|
| IC50 | 8±n/a nM |
|---|
| Citation |  Brown, BS; Keddy, R; Perner, RJ; DiDomenico, S; Koenig, JR; Jinkerson, TK; Hannick, SM; McDonald, HA; Bianchi, BR; Honore, P; Puttfarcken, PS; Moreland, RB; Marsh, KC; Faltynek, CR; Lee, CH Discovery of TRPV1 antagonist ABT-116. Bioorg Med Chem Lett20:3291-4 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily V member 1 |
|---|
| Name: | Transient receptor potential cation channel subfamily V member 1 |
|---|
| Synonyms: | Capsaicin receptor | OTRPC1 | Osm-9-like TRP channel 1 | TRPV1 | TRPV1_HUMAN | Transient receptor potential cation channel subfamily V member 1 | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Transient receptor potential cation channel subfamily V member 1 (VR1/TRPV1) | Transient receptor potential cation channel subfamily V member 1(TRPV1) | VR1 | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 | Vanilloid receptor 1 (TrpV1/Vr1) | Vanilloid receptor 1 (VRI/TRPV1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 94960.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8NER1 |
|---|
| Residue: | 839 |
|---|
| Sequence: | MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK
|
|
|
|---|
| BDBM50319466 |
|---|
| n/a |
|---|
| Name | BDBM50319466 |
|---|
| Synonyms: | 1-(1H-indazol-4-yl)-3-(2-(3-methoxypropyl)-4-(trifluoromethyl)benzyl)urea | CHEMBL1083713 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21F3N4O2 |
|---|
| Mol. Mass. | 406.4015 |
|---|
| SMILES | COCCCc1cc(ccc1CNC(=O)Nc1cccc2[nH]ncc12)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
