Compile Data Set for Download or QSAR

Found 1016 hits with Last Name = 'keddy' and Initial = 'r'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143965 (US8969325, 166) Show SMILES CN1C(=O)NCc2c(NC(=O)N[C@@H]3C[C@@](C)(Oc4ccccc34)C(F)(F)F)cccc12 Show InChI InChI=1S/C21H21F3N4O3/c1-20(21(22,23)24)10-15(12-6-3-4-9-17(12)31-20)27-18(29)26-14-7-5-8-16-13(14)11-25-19(30)28(16)2/h3-9,15H,10-11H2,1-2H3,(H,25,30)(H2,26,27,29)/t15-,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143964 (US8969325, 165) Show SMILES CN1C(=O)NCc2c(NC(=O)N[C@@H]3C[C@](C)(Oc4ccccc34)C(F)(F)F)cccc12 Show InChI InChI=1S/C21H21F3N4O3/c1-20(21(22,23)24)10-15(12-6-3-4-9-17(12)31-20)27-18(29)26-14-7-5-8-16-13(14)11-25-19(30)28(16)2/h3-9,15H,10-11H2,1-2H3,(H,25,30)(H2,26,27,29)/t15-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319456 (1-(1H-indazol-4-yl)-3-((2-(piperidin-1-yl)-6-(trif...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]ncc23)c(n1)N1CCCCC1 Show InChI InChI=1S/C20H21F3N6O/c21-20(22,23)17-8-7-13(18(27-17)29-9-2-1-3-10-29)11-24-19(30)26-15-5-4-6-16-14(15)12-25-28-16/h4-8,12H,1-3,9-11H2,(H,25,28)(H2,24,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143829 (US8969325, 30) Show SMILES C[C@@]1(C[C@@H](NC(=O)Nc2ccc3CCC(=O)Nc3c2)c2ccc(Cl)cc2O1)C(F)F Show InChI InChI=1S/C21H20ClF2N3O3/c1-21(19(23)24)10-16(14-6-4-12(22)8-17(14)30-21)27-20(29)25-13-5-2-11-3-7-18(28)26-15(11)9-13/h2,4-6,8-9,16,19H,3,7,10H2,1H3,(H,26,28)(H2,25,27,29)/t16-,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143834 (US8969325, 35) Show SMILES FC(F)(F)c1ccc2[C@@H](CCc2c1)NC(=O)Nc1ccc2CCC(=O)Nc2c1 Show InChI InChI=1S/C20H18F3N3O2/c21-20(22,23)13-4-6-15-12(9-13)2-7-16(15)26-19(28)24-14-5-1-11-3-8-18(27)25-17(11)10-14/h1,4-6,9-10,16H,2-3,7-8H2,(H,25,27)(H2,24,26,28)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319471 (1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl...) Show SMILES CC(C)(C)CCc1cc(ccc1CNC(=O)Nc1cccc2[nH]ncc12)C(F)(F)F Show InChI InChI=1S/C22H25F3N4O/c1-21(2,3)10-9-14-11-16(22(23,24)25)8-7-15(14)12-26-20(30)28-18-5-4-6-19-17(18)13-27-29-19/h4-8,11,13H,9-10,12H2,1-3H3,(H,27,29)(H2,26,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM144122 (US8969325, 323) Show SMILES FCC1(CF)C[C@@H](NC(=O)Nc2cccc3NC(=O)COc23)c2ccc(Cl)cc2O1 Show InChI InChI=1S/C20H18ClF2N3O4/c21-11-4-5-12-15(7-20(9-22,10-23)30-16(12)6-11)26-19(28)25-14-3-1-2-13-18(14)29-8-17(27)24-13/h1-6,15H,7-10H2,(H,24,27)(H2,25,26,28)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143966 (US8969325, 167) Show SMILES CN1Cc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4cc(Cl)ccc34)cccc2N(C)C1=O Show InChI InChI=1S/C22H23ClF2N4O3/c1-28-10-15-16(4-3-5-18(15)29(2)21(28)31)26-20(30)27-17-9-22(11-24,12-25)32-19-8-13(23)6-7-14(17)19/h3-8,17H,9-12H2,1-2H3,(H2,26,27,30)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319465 (1-((2-(3,3-dimethylbutyl)-6-(trifluoromethyl)pyrid...) Show SMILES CC(C)(C)CCc1nc(ccc1CNC(=O)Nc1cccc2[nH]ncc12)C(F)(F)F Show InChI InChI=1S/C21H24F3N5O/c1-20(2,3)10-9-15-13(7-8-18(27-15)21(22,23)24)11-25-19(30)28-16-5-4-6-17-14(16)12-26-29-17/h4-8,12H,9-11H2,1-3H3,(H,26,29)(H2,25,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186332 (US9163017, 6) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)-c3ccc(cc3)-c3c[nH]c(n3)[C@@H]3CCCN3C(=O)[C@H](N(C)C)c3ccccc3)ncnc2n1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186333 (US9163017, 7) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)C#Cc3ccc(NC(=O)[C@@H]4CCCN4C(=O)[C@H](N(C)C)c4ccccc4)cc3)ncnc2n1 |r| Show InChI InChI=1S/C45H44N8O2S/c1-29(2)37-24-23-36-42(50-37)47-28-48-43(36)51-38-27-31(16-25-40(38)56-35-21-17-33(46)18-22-35)13-12-30-14-19-34(20-15-30)49-44(54)39-11-8-26-53(39)45(55)41(52(3)4)32-9-6-5-7-10-32/h5-7,9-10,14-25,27-29,39,41H,8,11,26,46H2,1-4H3,(H,49,54)(H,47,48,50,51)/t39-,41+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186335 (US9163017, 9) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)C#Cc3ccc(cc3)-c3c[nH]c(n3)[C@@H]3CCCN3C(=O)[C@H](N(C)C)c3ccccc3)ncnc2n1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186336 (US9163017, 10) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)C#Cc3ccc(NC(=O)[C@@H]4CCCN4C(=O)[C@@H](Cc4ccccc4)N(C)C)cc3)ncnc2n1 |r| Show InChI InChI=1S/C46H46N8O2S/c1-30(2)38-24-23-37-43(51-38)48-29-49-44(37)52-39-27-33(16-25-42(39)57-36-21-17-34(47)18-22-36)13-12-31-14-19-35(20-15-31)50-45(55)40-11-8-26-54(40)46(56)41(53(3)4)28-32-9-6-5-7-10-32/h5-7,9-10,14-25,27,29-30,40-41H,8,11,26,28,47H2,1-4H3,(H,50,55)(H,48,49,51,52)/t40-,41+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186337 (US9163017, 11) Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)C#Cc1ccc(Sc2ccc(N)cc2)c(Nc2ncnc3nc(ccc23)C(C)C)c1 |r| Show InChI InChI=1S/C42H44N8O4S/c1-25(2)33-20-19-32-38(47-33)44-24-45-39(32)48-34-23-28(12-21-36(34)55-31-17-13-29(43)14-18-31)9-8-27-10-15-30(16-11-27)46-40(51)35-7-6-22-50(35)41(52)37(26(3)4)49-42(53)54-5/h10-21,23-26,35,37H,6-7,22,43H2,1-5H3,(H,46,51)(H,49,53)(H,44,45,47,48)/t35-,37-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186338 (US9163017, 12) Show SMILES COc1ccc(Sc2ccc(cc2Nc2ncnc3nc(ccc23)C(C)C)C#Cc2ccc(NC(=O)[C@@H]3CCCN3C(=O)OCc3ccccc3)cc2)cc1 |r| Show InChI InChI=1S/C44H40N6O4S/c1-29(2)37-23-22-36-41(48-37)45-28-46-42(36)49-38-26-31(15-24-40(38)55-35-20-18-34(53-3)19-21-35)12-11-30-13-16-33(17-14-30)47-43(51)39-10-7-25-50(39)44(52)54-27-32-8-5-4-6-9-32/h4-6,8-9,13-24,26,28-29,39H,7,10,25,27H2,1-3H3,(H,47,51)(H,45,46,48,49)/t39-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186339 (US9163017, 13) Show SMILES COc1ccc(Sc2ccc(cc2Nc2ncnc3nc(ccc23)C(C)C)C#Cc2ccc(cc2)-c2c[nH]c(n2)[C@@H]2CCCN2C(=O)[C@H](N(C)C)c2ccccc2)cc1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186342 (US9163017, 16) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)C(=O)Nc3cccc(NC(=O)[C@@H]4CCCN4C(=O)OCc4ccccc4)c3)ncnc2n1 |r| Show InChI InChI=1S/C42H40N8O4S/c1-26(2)34-19-18-33-38(48-34)44-25-45-39(33)49-35-22-28(13-20-37(35)55-32-16-14-29(43)15-17-32)40(51)46-30-10-6-11-31(23-30)47-41(52)36-12-7-21-50(36)42(53)54-24-27-8-4-3-5-9-27/h3-6,8-11,13-20,22-23,25-26,36H,7,12,21,24,43H2,1-2H3,(H,46,51)(H,47,52)(H,44,45,48,49)/t36-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186343 (US9163017, 17) Show SMILES CC(C)c1ccc2c(Nc3cc(NC(=O)[C@@H]4CCCN4C(=O)OCc4ccccc4)ccc3Sc3ccc(N)cc3)ncnc2n1 |r| Show InChI InChI=1S/C35H35N7O3S/c1-22(2)28-16-15-27-32(40-28)37-21-38-33(27)41-29-19-25(12-17-31(29)46-26-13-10-24(36)11-14-26)39-34(43)30-9-6-18-42(30)35(44)45-20-23-7-4-3-5-8-23/h3-5,7-8,10-17,19,21-22,30H,6,9,18,20,36H2,1-2H3,(H,39,43)(H,37,38,40,41)/t30-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186331 (US9163017, 5) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)C#Cc3ccc(NC(=O)[C@@H]4CCCN4C(=O)OCc4ccccc4)cc3)ncnc2n1 |r| Show InChI InChI=1S/C43H39N7O3S/c1-28(2)36-22-21-35-40(48-36)45-27-46-41(35)49-37-25-30(14-23-39(37)54-34-19-15-32(44)16-20-34)11-10-29-12-17-33(18-13-29)47-42(51)38-9-6-24-50(38)43(52)53-26-31-7-4-3-5-8-31/h3-5,7-8,12-23,25,27-28,38H,6,9,24,26,44H2,1-2H3,(H,47,51)(H,45,46,48,49)/t38-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186324 (US9163017, 3) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)C(=O)Nc3ccc(NC(=O)C4CCCN4C(=O)OCc4ccccc4)cc3)ncnc2n1 Show InChI InChI=1S/C42H40N8O4S/c1-26(2)34-20-19-33-38(48-34)44-25-45-39(33)49-35-23-28(10-21-37(35)55-32-17-11-29(43)12-18-32)40(51)46-30-13-15-31(16-14-30)47-41(52)36-9-6-22-50(36)42(53)54-24-27-7-4-3-5-8-27/h3-5,7-8,10-21,23,25-26,36H,6,9,22,24,43H2,1-2H3,(H,46,51)(H,47,52)(H,44,45,48,49)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186318 (US9163017, 2) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)C(=O)Nc3ccc(cc3)-c3c[nH]c(n3)[C@@H]3CCCN3C(=O)[C@H](N(C)C)c3ccccc3)ncnc2n1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM186334 (US9163017, 8) Show SMILES CC(C)c1ccc2c(Nc3cc(ccc3Sc3ccc(N)cc3)-c3ccc(cc3)-c3ccc(cc3)-c3c[nH]c(n3)[C@@H]3CCCN3C(=O)[C@H](N(C)C)c3ccccc3)ncnc2n1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The inhibitory effects of the compounds of the invention on HCV replication can be determined by measuring activity of the luciferase reporter gene. ...				US Patent US9163017 (2015) BindingDB Entry DOI: 10.7270/Q2F47MX7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264620 (CHEMBL518979 | N-(4-tert-Butylphenyl)-1-(3-(triflu...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2C(F)(F)F)cc1 |t:11| Show InChI InChI=1S/C22H24F3N3O/c1-21(2,3)16-6-8-17(9-7-16)27-20(29)15-10-13-28(14-11-15)19-18(22(23,24)25)5-4-12-26-19/h4-10,12H,11,13-14H2,1-3H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319464 (1-(1H-indazol-4-yl)-3-((2-(neopentyloxy)-6-(triflu...) Show SMILES CC(C)(C)COc1nc(ccc1CNC(=O)Nc1cccc2[nH]ncc12)C(F)(F)F Show InChI InChI=1S/C20H22F3N5O2/c1-19(2,3)11-30-17-12(7-8-16(27-17)20(21,22)23)9-24-18(29)26-14-5-4-6-15-13(14)10-25-28-15/h4-8,10H,9,11H2,1-3H3,(H,25,28)(H2,24,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319470 (1-(2-(3-fluoro-3-methylbutyl)-4-(trifluoromethyl)b...) Show SMILES CC(C)(F)CCc1cc(ccc1CNC(=O)Nc1cccc2[nH]ncc12)C(F)(F)F Show InChI InChI=1S/C21H22F4N4O/c1-20(2,22)9-8-13-10-15(21(23,24)25)7-6-14(13)11-26-19(30)28-17-4-3-5-18-16(17)12-27-29-18/h3-7,10,12H,8-9,11H2,1-2H3,(H,27,29)(H2,26,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143833 (US8969325, 34) Show SMILES C[C@@]1(C[C@@H](NC(=O)Nc2ccc3CCC(=O)Nc3c2)c2ccccc2O1)C(F)(F)F Show InChI InChI=1S/C21H20F3N3O3/c1-20(21(22,23)24)11-16(14-4-2-3-5-17(14)30-20)27-19(29)25-13-8-6-12-7-9-18(28)26-15(12)10-13/h2-6,8,10,16H,7,9,11H2,1H3,(H,26,28)(H2,25,27,29)/t16-,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319454 (1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl...) Show SMILES Cn1ncc2c(NC(=O)NCc3ccc(cc3CCC(C)(C)C)C(F)(F)F)cccc12 Show InChI InChI=1S/C23H27F3N4O/c1-22(2,3)11-10-15-12-17(23(24,25)26)9-8-16(15)13-27-21(31)29-19-6-5-7-20-18(19)14-28-30(20)4/h5-9,12,14H,10-11,13H2,1-4H3,(H2,27,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	5.5	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced effect at pH 5.5				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319467 (1-(1H-indazol-4-yl)-3-(2-phenethyl-4-(trifluoromet...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]ncc23)c(CCc2ccccc2)c1 Show InChI InChI=1S/C24H21F3N4O/c25-24(26,27)19-12-11-18(17(13-19)10-9-16-5-2-1-3-6-16)14-28-23(32)30-21-7-4-8-22-20(21)15-29-31-22/h1-8,11-13,15H,9-10,14H2,(H,29,31)(H2,28,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319466 (1-(1H-indazol-4-yl)-3-(2-(3-methoxypropyl)-4-(trif...) Show SMILES COCCCc1cc(ccc1CNC(=O)Nc1cccc2[nH]ncc12)C(F)(F)F Show InChI InChI=1S/C20H21F3N4O2/c1-29-9-3-4-13-10-15(20(21,22)23)8-7-14(13)11-24-19(28)26-17-5-2-6-18-16(17)12-25-27-18/h2,5-8,10,12H,3-4,9,11H2,1H3,(H,25,27)(H2,24,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143895 (US8969325, 96) Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3CCc4cc(Cl)ccc34)c2ccc1=O Show InChI InChI=1S/C20H18ClN3O2/c1-24-18-4-2-3-16(15(18)8-10-19(24)25)22-20(26)23-17-9-5-12-11-13(21)6-7-14(12)17/h2-4,6-8,10-11,17H,5,9H2,1H3,(H2,22,23,26)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264703 (CHEMBL522425 | N-(4-(Trifluoromethyl)phenyl)-1-(3-...) Show SMILES FC(F)(F)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2C(F)(F)F)cc1 |t:11| Show InChI InChI=1S/C19H15F6N3O/c20-18(21,22)13-3-5-14(6-4-13)27-17(29)12-7-10-28(11-8-12)16-15(19(23,24)25)2-1-9-26-16/h1-7,9H,8,10-11H2,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143933 (US8969325, 134) Show SMILES C[C@H]1Oc2c(NC(=O)N[C@@H]3CC(CF)(CF)Oc4cc(Cl)ccc34)cccc2NC1=O Show InChI InChI=1S/C21H20ClF2N3O4/c1-11-19(28)25-14-3-2-4-15(18(14)30-11)26-20(29)27-16-8-21(9-23,10-24)31-17-7-12(22)5-6-13(16)17/h2-7,11,16H,8-10H2,1H3,(H,25,28)(H2,26,27,29)/t11-,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319468 (1-(1H-indazol-4-yl)-3-(2-phenoxy-4-(trifluoromethy...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]ncc23)c(Oc2ccccc2)c1 Show InChI InChI=1S/C22H17F3N4O2/c23-22(24,25)15-10-9-14(20(11-15)31-16-5-2-1-3-6-16)12-26-21(30)28-18-7-4-8-19-17(18)13-27-29-19/h1-11,13H,12H2,(H,27,29)(H2,26,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319469 (1-(1H-indazol-4-yl)-3-(2-isopropyl-4-(trifluoromet...) Show SMILES CC(C)c1cc(ccc1CNC(=O)Nc1cccc2[nH]ncc12)C(F)(F)F Show InChI InChI=1S/C19H19F3N4O/c1-11(2)14-8-13(19(20,21)22)7-6-12(14)9-23-18(27)25-16-4-3-5-17-15(16)10-24-26-17/h3-8,10-11H,9H2,1-2H3,(H,24,26)(H2,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319461 (1-(1H-indazol-4-yl)-3-((2-phenoxy-6-(trifluorometh...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]ncc23)c(Oc2ccccc2)n1 Show InChI InChI=1S/C21H16F3N5O2/c22-21(23,24)18-10-9-13(19(28-18)31-14-5-2-1-3-6-14)11-25-20(30)27-16-7-4-8-17-15(16)12-26-29-17/h1-10,12H,11H2,(H,26,29)(H2,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264621 (CHEMBL482835 | N-(4-tert-Butylphenyl)-1-(3-chlorop...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2Cl)cc1 |t:11| Show InChI InChI=1S/C21H24ClN3O/c1-21(2,3)16-6-8-17(9-7-16)24-20(26)15-10-13-25(14-11-15)19-18(22)5-4-12-23-19/h4-10,12H,11,13-14H2,1-3H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264668 (CHEMBL491234 | N-(4-tert-Butylphenyl)-1-(pyrimidin...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ncccn2)cc1 |t:11| Show InChI InChI=1S/C20H24N4O/c1-20(2,3)16-5-7-17(8-6-16)23-18(25)15-9-13-24(14-10-15)19-21-11-4-12-22-19/h4-9,11-12H,10,13-14H2,1-3H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143800 (US8969325, 1) Show SMILES CN1C(=O)NCc2c(NC(=O)N[C@@H]3CC(C)(C)Oc4cc(F)ccc34)cccc12 Show InChI InChI=1S/C21H23FN4O3/c1-21(2)10-16(13-8-7-12(22)9-18(13)29-21)25-19(27)24-15-5-4-6-17-14(15)11-23-20(28)26(17)3/h4-9,16H,10-11H2,1-3H3,(H,23,28)(H2,24,25,27)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143885 (US8969325, 86) Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3CCc4cc(ccc34)C(F)(F)F)c2ccc1=O Show InChI InChI=1S/C21H18F3N3O2/c1-27-18-4-2-3-16(15(18)8-10-19(27)28)25-20(29)26-17-9-5-12-11-13(21(22,23)24)6-7-14(12)17/h2-4,6-8,10-11,17H,5,9H2,1H3,(H2,25,26,29)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143818 (US8969325, 19) Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3CC(C)(C)Oc4cc(F)ccc34)c2ccc1=O Show InChI InChI=1S/C22H22FN3O3/c1-22(2)12-17(15-8-7-13(23)11-19(15)29-22)25-21(28)24-16-5-4-6-18-14(16)9-10-20(27)26(18)3/h4-11,17H,12H2,1-3H3,(H2,24,25,28)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143889 (US8969325, 90) Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3C[C@@](C)(Oc4ccccc34)C(F)(F)F)c2ccc1=O Show InChI InChI=1S/C22H20F3N3O3/c1-21(22(23,24)25)12-16(14-6-3-4-9-18(14)31-21)27-20(30)26-15-7-5-8-17-13(15)10-11-19(29)28(17)2/h3-11,16H,12H2,1-2H3,(H2,26,27,30)/t16-,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143939 (US8969325, 140) Show SMILES CCC1(CC)C[C@@H](NC(=O)Nc2cccc3N(C)C(=O)NCc23)c2ccccc2O1 Show InChI InChI=1S/C23H28N4O3/c1-4-23(5-2)13-18(15-9-6-7-12-20(15)30-23)26-21(28)25-17-10-8-11-19-16(17)14-24-22(29)27(19)3/h6-12,18H,4-5,13-14H2,1-3H3,(H,24,29)(H2,25,26,28)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319459 (1-(1H-indazol-4-yl)-3-((2-morpholino-6-(trifluorom...) Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]ncc23)c(n1)N1CCOCC1 Show InChI InChI=1S/C19H19F3N6O2/c20-19(21,22)16-5-4-12(17(26-16)28-6-8-30-9-7-28)10-23-18(29)25-14-2-1-3-15-13(14)11-24-27-15/h1-5,11H,6-10H2,(H,24,27)(H2,23,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50319463 (1-(1H-indazol-4-yl)-3-((2-(3-methoxypropyl)-6-(tri...) Show SMILES COCCCc1nc(ccc1CNC(=O)Nc1cccc2[nH]ncc12)C(F)(F)F Show InChI InChI=1S/C19H20F3N5O2/c1-29-9-3-6-14-12(7-8-17(25-14)19(20,21)22)10-23-18(28)26-15-4-2-5-16-13(15)11-24-27-16/h2,4-5,7-8,11H,3,6,9-10H2,1H3,(H,24,27)(H2,23,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1				Bioorg Med Chem Lett 20: 3291-4 (2010) Article DOI: 10.1016/j.bmcl.2010.04.047 BindingDB Entry DOI: 10.7270/Q2B27VF7
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM144119 (US8969325, 320) Show SMILES FCC1(CF)C[C@@H](NC(=O)Nc2ccc3CCC(=O)Nc3c2)c2ccc(cc2O1)C(F)(F)F Show InChI InChI=1S/C22H20F5N3O3/c23-10-21(11-24)9-17(15-5-3-13(22(25,26)27)7-18(15)33-21)30-20(32)28-14-4-1-12-2-6-19(31)29-16(12)8-14/h1,3-5,7-8,17H,2,6,9-11H2,(H,29,31)(H2,28,30,32)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143827 (US8969325, 28) Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3C[C@@](C)(Oc4ccccc34)C(F)F)c2ccc1=O Show InChI InChI=1S/C22H21F2N3O3/c1-22(20(23)24)12-16(14-6-3-4-9-18(14)30-22)26-21(29)25-15-7-5-8-17-13(15)10-11-19(28)27(17)2/h3-11,16,20H,12H2,1-2H3,(H2,25,26,29)/t16-,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143840 (US8969325, 41) Show SMILES Cn1c2cccc(NC(=O)N[C@@H]3C[C@@](C)(CF)Oc4cc(Cl)ccc34)c2ccc1=O Show InChI InChI=1S/C22H21ClFN3O3/c1-22(12-24)11-17(15-7-6-13(23)10-19(15)30-22)26-21(29)25-16-4-3-5-18-14(16)8-9-20(28)27(18)2/h3-10,17H,11-12H2,1-2H3,(H2,25,26,29)/t17-,22+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM143938 (US8969325, 139) Show SMILES CCC1(CC)C[C@@H](NC(=O)Nc2cccc3N(C)C(=O)NCc23)c2cccc(F)c2O1 Show InChI InChI=1S/C23H27FN4O3/c1-4-23(5-2)12-18(14-8-6-9-16(24)20(14)31-23)27-21(29)26-17-10-7-11-19-15(17)13-25-22(30)28(19)3/h6-11,18H,4-5,12-13H2,1-3H3,(H,25,30)(H2,26,27,29)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM144051 (US8969325, 252) Show SMILES FCC1(CF)C[C@@H](NC(=S)Nc2ccc3CCC(=O)Nc3c2)c2ccc(Cl)cc2O1 Show InChI InChI=1S/C21H20ClF2N3O2S/c22-13-3-5-15-17(9-21(10-23,11-24)29-18(15)7-13)27-20(30)25-14-4-1-12-2-6-19(28)26-16(12)8-14/h1,3-5,7-8,17H,2,6,9-11H2,(H,26,28)(H2,25,27,30)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...				US Patent US8969325 (2015) BindingDB Entry DOI: 10.7270/Q29P30BX
					More data for this Ligand-Target Pair

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