| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Ligand | BDBM50320792 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639169 (CHEMBL1167430) |
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| Ki | 5.68±n/a nM |
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| Citation |  Schormann, N; Velu, SE; Murugesan, S; Senkovich, O; Walker, K; Chenna, BC; Shinkre, B; Desai, A; Chattopadhyay, D Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase. Bioorg Med Chem18:4056-66 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Synonyms: | DRTS_TRYCR |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58857.11 |
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| Organism: | Trypanosoma cruzi |
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| Description: | ChEMBL_639165 |
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| Residue: | 521 |
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| Sequence: | MSLFKIRMPETVAEGTRLALRAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLR
GKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNL
HADSIVAVNGGLEQALRLLASPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTI
RASESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKYYFEKLIPRNREEEQY
LSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFL
RGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHHDAN
YDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSNGELSCML
YQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCNEQLKRV
PRAFPYLVFRREREFLEDYEEGDMEVIDYAPYPPISMKMAV
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| BDBM50320792 |
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| n/a |
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| Name | BDBM50320792 |
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| Synonyms: | CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate | ethyl 4-(5-{[(2,4-diaminoquinazolin-6-yl)methyl]amino}-2-methoxyphenoxy)butanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N5O4 |
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| Mol. Mass. | 425.4809 |
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| SMILES | CCOC(=O)CCCOc1cc(NCc2ccc3nc(N)nc(N)c3c2)ccc1OC |
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| Structure | 
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