| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-galactosidase A |
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| Ligand | BDBM50163440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639188 (CHEMBL1168041) |
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| IC50 | 70±n/a nM |
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| Citation |  Kato, A; Yamashita, Y; Nakagawa, S; Koike, Y; Adachi, I; Hollinshead, J; Nash, RJ; Ikeda, K; Asano, N 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem18:3790-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-galactosidase A |
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| Name: | Alpha-galactosidase A |
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| Synonyms: | AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase |
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| Type: | Protein |
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| Mol. Mass.: | 48760.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 429 |
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| Sequence: | MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL
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| BDBM50163440 |
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| n/a |
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| Name | BDBM50163440 |
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| Synonyms: | (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | (2R,3S,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol | 1-deoxygalactonojirimycin | CHEMBL110458 | D-galacto-1-Deoxynojirimycin | DGJ |
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| Type | Small organic molecule |
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| Emp. Form. | C6H13NO4 |
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| Mol. Mass. | 163.1717 |
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| SMILES | OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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