| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thermolysin |
|---|
| Ligand | BDBM50321123 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_637433 (CHEMBL1166366) |
|---|
| IC50 | 247.70±n/a nM |
|---|
| Citation |  Khan, MT; Khan, R; Wuxiuer, Y; Arfan, M; Ahmed, M; Sylte, I Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases. Bioorg Med Chem18:4317-27 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thermolysin |
|---|
| Name: | Thermolysin |
|---|
| Synonyms: | THER_BACTH | npr |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60097.54 |
|---|
| Organism: | Bacillus thermoproteolyticus |
|---|
| Description: | ChEMBL_1468794 |
|---|
| Residue: | 548 |
|---|
| Sequence: | MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLLKVNGTSPEEL
VYQYVEKNENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTSHVKDG
TLTALSGTLIPNLDTKGSLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVY
VNGDEASLAYVVNLNFLTPEPGNWLYIIDAVDGKILNKFNQLDAAKPGDVKSITGTSTVG
VGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDA
PAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQ
TFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEI
GEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGG
THYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQ
AFDAVGVK
|
|
|
|---|
| BDBM50321123 |
|---|
| n/a |
|---|
| Name | BDBM50321123 |
|---|
| Synonyms: | 3-(Isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one | CHEMBL1163762 | cid_949175 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H17N3O |
|---|
| Mol. Mass. | 231.2936 |
|---|
| SMILES | [#6]\[#6](-[#6])=[#7]\[#7]1-[#6](=O)-c2ccccc2-[#7]C1([#6])[#6] |
|---|
| Structure | 
|
|---|
Search and Browse
