| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50323005 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_643523 (CHEMBL1212387) |
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| IC50 | 4.3±n/a nM |
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| Citation |  Hortala, L; Rinaldi-Carmona, M; Congy, C; Boulu, L; Sadoun, F; Fabre, G; Finance, O; Barth, F Rational design of a novel peripherally-restricted, orally active CB(1) cannabinoid antagonist containing a 2,3-diarylpyrrole motif. Bioorg Med Chem Lett20:4573-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52856.55 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P20272 |
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| Residue: | 473 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAI
AVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHV
FHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCL
MWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILW
KAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPL
LAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTA
QPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50323005 |
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| n/a |
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| Name | BDBM50323005 |
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| Synonyms: | 1'-(5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-(3-(methylsulfonamido)propyl)-1H-pyrrole-2-carbonyl)-4,4-dimethyl-1,4'-bipiperidine-4'-carboxamide | CHEMBL1210781 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H42Cl3N5O4S |
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| Mol. Mass. | 723.152 |
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| SMILES | CC1(C)CCN(CC1)C1(CCN(CC1)C(=O)c1cc(c(-c2ccc(Cl)cc2)n1CCCNS(C)(=O)=O)-c1ccc(Cl)cc1Cl)C(N)=O |
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| Structure | 
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