Ki Summary

Reaction Details

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Target

Melanocortin receptor 3

Ligand

BDBM50323441

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_644103 (CHEMBL1212002)

EC50

767±n/a nM

Citation

Guo, L; Ye, Z; Liu, J; He, S; Bakshi, RK; Sebhat, IK; Dobbelaar, PH; Hong, Q; Jian, T; Dellureficio, JP; Tsou, NN; Ball, RG; Weinberg, DH; MacNeil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Chen, HY; Chen, AS; Martin, WJ; MacIntyre, DE; Strack, AM; Fong, TM; Wyvratt, MJ; Nargund, RP Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists. Bioorg Med Chem Lett20:4895-900 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 3

Name:

Melanocortin receptor 3

Synonyms:

MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)

Type:

Enzyme

Mol. Mass.:

36044.86

Organism:

Homo sapiens (Human)

Description:

P41968

Residue:

323

Sequence:

MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG

BDBM50323441

n/a

Name

BDBM50323441

Synonyms:

2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile | CHEMBL1209788

Type

Small organic molecule

Emp. Form.

C33H38ClF2N3O3

Mol. Mass.

598.123

SMILES

Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)C#N |r|

Structure