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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM50323522 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_644901 (CHEMBL1211231) | ||
| EC50 | 536±n/a nM | ||
| Citation |  Abel, U; Schlüter, T; Schulz, A; Hambruch, E; Steeneck, C; Hornberger, M; Hoffmann, T; Perovic-Ottstadt, S; Kinzel, O; Burnet, M; Deuschle, U; Kremoser, C Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. Bioorg Med Chem Lett20:4911-7 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
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| BDBM50323522 | |||
| n/a | |||
| Name | BDBM50323522 | ||
| Synonyms: | 3-(2,6-dichlorophenyl)-5-isopropyl-4-((4-methylquinolin-2-yloxy)methyl)isoxazole | CHEMBL1209060 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H20Cl2N2O2 | ||
| Mol. Mass. | 427.323 | ||
| SMILES | CC(C)c1onc(c1COc1cc(C)c2ccccc2n1)-c1c(Cl)cccc1Cl |(-5.54,-39.13,;-4.92,-37.72,;-3.39,-37.56,;-5.83,-36.48,;-7.37,-36.48,;-7.84,-35.02,;-6.6,-34.12,;-5.35,-35.01,;-4.01,-34.26,;-2.69,-35.05,;-1.34,-34.31,;-1.33,-32.77,;.01,-32.02,;.03,-30.48,;1.34,-32.81,;2.68,-32.07,;4,-32.85,;3.98,-34.39,;2.63,-35.14,;1.32,-34.35,;-.03,-35.1,;-6.6,-32.58,;-7.93,-31.81,;-9.26,-32.58,;-7.93,-30.26,;-6.6,-29.49,;-5.26,-30.26,;-5.26,-31.81,;-3.92,-32.57,)| | ||
| Structure | 
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