Reaction Details |
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Target | Transmembrane protease serine 6 |
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Ligand | BDBM50324476 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_649221 (CHEMBL1218919) |
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Ki | >10000±n/a nM |
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Citation | Sisay, MT; Steinmetzer, T; Stirnberg, M; Maurer, E; Hammami, M; Bajorath, J; Gütschow, M Identification of the first low-molecular-weight inhibitors of matriptase-2. J Med Chem53:5523-35 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transmembrane protease serine 6 |
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Name: | Transmembrane protease serine 6 |
Synonyms: | Matriptase-2 | TMPRSS6 | TMPS6_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 90001.12 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1442547 |
Residue: | 811 |
Sequence: | MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLL
ALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
MLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELL
STVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDH
LASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVE
VLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYY
SPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAE
RIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDC
PNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCED
RSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRH
ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYH
EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNAL
QKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGL
VSWGLGCGRPNYFGVYTRITGVISWIQQVVT
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BDBM50324476 |
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n/a |
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Name | BDBM50324476 |
Synonyms: | Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-chlorobenzyl)-amide Bis(trifluoroacetate) | CHEMBL1215084 |
Type | Small organic molecule |
Emp. Form. | C26H36ClN7O4S |
Mol. Mass. | 578.127 |
SMILES | NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1 |r| |
Structure |
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