Reaction Details |
| Report a problem with these data |
Target | Hematopoietic prostaglandin D synthase |
---|
Ligand | BDBM21625 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_649226 (CHEMBL1218924) |
---|
IC50 | 700±n/a nM |
---|
Citation | Christ, AN; Labzin, L; Bourne, GT; Fukunishi, H; Weber, JE; Sweet, MJ; Smythe, ML; Flanagan, JU Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases. J Med Chem53:5536-48 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Hematopoietic prostaglandin D synthase |
---|
Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
|
|
|
BDBM21625 |
---|
n/a |
---|
Name | BDBM21625 |
Synonyms: | 2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 2-phenyl-5-(1H-pyrazol-5-yl)thiazole | Pyrazolylthiazole, 13 |
Type | Small organic molecule |
Emp. Form. | C12H9N3S |
Mol. Mass. | 227.285 |
SMILES | c1cc(n[nH]1)-c1cnc(s1)-c1ccccc1 |
Structure |
|