| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
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| Ligand | BDBM50324668 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_653483 (CHEMBL1226686) |
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| Ki | 23±n/a nM |
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| Citation |  Murray, CM; Hutchinson, R; Bantick, JR; Belfield, GP; Benjamin, AD; Brazma, D; Bundick, RV; Cook, ID; Craggs, RI; Edwards, S; Evans, LR; Harrison, R; Holness, E; Jackson, AP; Jackson, CG; Kingston, LP; Perry, MW; Ross, AR; Rugman, PA; Sidhu, SS; Sullivan, M; Taylor-Fishwick, DA; Walker, PC; Whitehead, YM; Wilkinson, DJ; Wright, A; Donald, DK Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat Chem Biol1:371-6 (2005) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 1 |
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| Name: | Monocarboxylate transporter 1 |
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| Synonyms: | MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53956.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451367 |
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| Residue: | 500 |
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| Sequence: | MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
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|
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| BDBM50324668 |
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| n/a |
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| Name | BDBM50324668 |
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| Synonyms: | 6-[[4-azido-3-(iodo-125I)phenyl]methyl]-2,6-dihydro-2-methyl-4-(2-methylpropyl)-1H-pyrrolo[3,4-d]pyridazin-1-one | CHEMBL1221509 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19IN6O |
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| Mol. Mass. | 462.2875 |
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| SMILES | CC(C)Cc1nn(C)c(=O)c2cn(Cc3ccc(N=[N+]=[N-])c(I)c3)cc12 |
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| Structure | 
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