Reaction Details |
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Target | Collagenase 3 |
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Ligand | BDBM50325347 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_652122 (CHEMBL1228231) |
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IC50 | 4±n/a nM |
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Citation | Gao, DA; Xiong, Z; Heim-Riether, A; Amodeo, L; August, EM; Cao, X; Ciccarelli, L; Collins, BK; Harrington, K; Haverty, K; Hill-Drzewi, M; Li, X; Liang, S; Margarit, SM; Moss, N; Nagaraja, N; Proudfoot, J; Roman, R; Schlyer, S; Keenan, LS; Taylor, S; Wellenzohn, B; Wiedenmayer, D; Li, J; Farrow, NA SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability. Bioorg Med Chem Lett20:5039-43 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Collagenase 3 |
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Name: | Collagenase 3 |
Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
Type: | Enzyme |
Mol. Mass.: | 53808.06 |
Organism: | Homo sapiens (Human) |
Description: | P45452 |
Residue: | 471 |
Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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BDBM50325347 |
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n/a |
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Name | BDBM50325347 |
Synonyms: | (R)-N-(3-(5-(1-cyclohexyl-2-(methylamino)-2-oxoethylcarbamoyl)furan-2-yl)benzyl)-6-methylpicolinamide | CHEMBL1223285 |
Type | Small organic molecule |
Emp. Form. | C28H32N4O4 |
Mol. Mass. | 488.5781 |
SMILES | CNC(=O)[C@H](NC(=O)c1ccc(o1)-c1cccc(CNC(=O)c2cccc(C)n2)c1)C1CCCCC1 |r| |
Structure |
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