| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50325867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_652659 (CHEMBL1225862) |
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| IC50 | 17039±n/a nM |
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| Citation |  Brugel, TA; Smith, RW; Balestra, M; Becker, C; Daniels, T; Koether, GM; Throner, SR; Panko, LM; Brown, DG; Liu, R; Gordon, J; Peters, MF SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2. Bioorg Med Chem Lett20:5405-10 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44789.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35372 |
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| Residue: | 400 |
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| Sequence: | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50325867 |
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| n/a |
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| Name | BDBM50325867 |
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| Synonyms: | CHEMBL1224140 | endo-3-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylbenzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N2O2 |
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| Mol. Mass. | 350.454 |
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| SMILES | Cc1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)cc(c1)C(N)=O |r,TLB:13:12:11.5.6:9.8| |
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| Structure | 
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