| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein phosphatase 1 |
|---|
| Ligand | BDBM50326052 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_655625 (CHEMBL1244669) |
|---|
| IC50 | 11500±n/a nM |
|---|
| Citation |  Molina, G; Vogt, A; Bakan, A; Dai, W; Queiroz de Oliveira, P; Znosko, W; Smithgall, TE; Bahar, I; Lazo, JS; Day, BW; Tsang, M Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol5:680-7 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein phosphatase 1 |
|---|
| Name: | Dual specificity protein phosphatase 1 |
|---|
| Synonyms: | CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1 |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 39301.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_4758204 |
|---|
| Residue: | 367 |
|---|
| Sequence: | MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM
GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF
LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF
LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA
IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS
FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP
ITTSPSC
|
|
|
|---|
| BDBM50326052 |
|---|
| n/a |
|---|
| Name | BDBM50326052 |
|---|
| Synonyms: | (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one | CHEMBL1241589 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23NO |
|---|
| Mol. Mass. | 317.4241 |
|---|
| SMILES | O=C1\C(=C\c2ccccc2)C(NC2CCCCC2)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
