Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50327148 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_663804 (CHEMBL1250704) |
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IC50 | 14±n/a nM |
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Citation | Misra, M; Shi, Q; Ye, X; Gruszecka-Kowalik, E; Bu, W; Liu, Z; Schweri, MM; Deutsch, HM; Venanzi, CA Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem18:7221-38 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68749.45 |
Organism: | Rattus norvegicus (rat) |
Description: | P23977 |
Residue: | 619 |
Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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BDBM50327148 |
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n/a |
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Name | BDBM50327148 |
Synonyms: | (R)-methyl 2-(4-iodophenyl)-2-((R)-piperidin-2-yl)acetate | CHEMBL1253735 |
Type | Small organic molecule |
Emp. Form. | C14H18INO2 |
Mol. Mass. | 359.2027 |
SMILES | COC(=O)[C@@H]([C@H]1CCCCN1)c1ccc(I)cc1 |r| |
Structure |
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