| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50327294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664345 (CHEMBL1259494) |
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| IC50 | 138±n/a nM |
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| Citation |  Lacombe, P; Aspiotis, R; Bayly, C; Chen, A; Dubé, D; Fortin, R; Gallant, M; Juteau, H; Liu, S; McKay, D; Roy, P; Wu, T Identification of a new biaryl scaffold generating potent renin inhibitors. Bioorg Med Chem Lett20:5822-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50327294 |
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| n/a |
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| Name | BDBM50327294 |
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| Synonyms: | CHEMBL1258168 | N-((4'-(1-amino-3-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)propan-2-yl)-3'-methylbiphenyl-2-yl)methyl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C34H36Cl2N2O3 |
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| Mol. Mass. | 591.567 |
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| SMILES | CC(=O)NCc1ccccc1-c1ccc(C(CN)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(C)c1 |
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| Structure | 
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