| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Renin |
|---|
| Ligand | BDBM50325178 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_664344 (CHEMBL1259493) |
|---|
| IC50 | 0.09±n/a nM |
|---|
| Citation |  Lacombe, P; Aspiotis, R; Bayly, C; Chen, A; Dubé, D; Fortin, R; Gallant, M; Juteau, H; Liu, S; McKay, D; Roy, P; Wu, T Identification of a new biaryl scaffold generating potent renin inhibitors. Bioorg Med Chem Lett20:5822-6 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Renin |
|---|
| Name: | Renin |
|---|
| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45058.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 406 |
|---|
| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
|---|
| BDBM50325178 |
|---|
| n/a |
|---|
| Name | BDBM50325178 |
|---|
| Synonyms: | (R)-3-amino-N-(2-chloro-5-(3-methoxypropyl)benzyl)-N-cyclopropyl-2-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzyl)propanamide | CHEMBL1222884 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H39Cl3N2O4 |
|---|
| Mol. Mass. | 634.033 |
|---|
| SMILES | COCCCc1ccc(Cl)c(CN(C2CC2)C(=O)[C@@H](CN)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
