Reaction Details |
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Target | Renin |
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Ligand | BDBM50328872 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_673945 (CHEMBL1275122) |
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IC50 | 3.40±n/a nM |
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Citation | Corminboeuf, O; Bezençon, O; Grisostomi, C; Remen, L; Richard-Bildstein, S; Bur, D; Prade, L; Hess, P; Strickner, P; Fischli, W; Steiner, B; Treiber, A Design and optimization of new piperidines as renin inhibitors. Bioorg Med Chem Lett20:6286-90 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50328872 |
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n/a |
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Name | BDBM50328872 |
Synonyms: | (3R,4S)-N-(2-chloro-5-(2-(cyclopropylamino)-2-oxoethyl)benzyl)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-3-carboxamide | CHEMBL1269690 |
Type | Small organic molecule |
Emp. Form. | C36H40Cl3N3O4 |
Mol. Mass. | 685.08 |
SMILES | Cc1cc(Cl)c(OCCOc2ccc(cc2)[C@H]2CCNC[C@@H]2C(=O)N(Cc2cc(CC(=O)NC3CC3)ccc2Cl)C2CC2)c(Cl)c1 |r| |
Structure |
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