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TargetMelanocortin receptor 4
LigandBDBM50329959
Substrate/Competitorn/a
Meas. Tech.ChEMBL_675993
EC50 0.11±n/a nM
Citation He SYe ZDobbelaar PHBakshi RKHong QDellureficio JPSebhat IKGuo LLiu JJian TLai YFranklin CLReibarkh MHolmes MAWeinberg DHMacNeil TTang RTamvakopoulos CPeng QMiller RRStearns RAChen HYChen ASStrack AMFong TMWyvratt MJNargund RP Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity. Bioorg Med Chem Lett 20:6524-32 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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  Blast E-value cutoff:
BDBM50329959
n/a
NameBDBM50329959
Synonyms:(6-chloro-5-methyl-3-(2-(1-methyl-1H-1,2,4-triazol-5-yl)propan-2-yl)-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)((1R,2R)-2-(2,4-difluorophenyl)-4-(methyl(tetrahydro-2H-pyran-4-yl)amino)cyclopentyl)methanone | CHEMBL1269576
TypeSmall organic molecule
Emp. Form.C38H48ClF2N5O2
Mol. Mass.680.27
SMILESCN(C1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCC2(C[C@@H](c3cc(C)c(Cl)cc23)C(C)(C)c2ncnn2C)CC1)C1CCOCC1 |r|
Structure
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