| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50329959 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675993 (CHEMBL1272931) |
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| EC50 | 0.11±n/a nM |
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| Citation |  He, S; Ye, Z; Dobbelaar, PH; Bakshi, RK; Hong, Q; Dellureficio, JP; Sebhat, IK; Guo, L; Liu, J; Jian, T; Lai, Y; Franklin, CL; Reibarkh, M; Holmes, MA; Weinberg, DH; MacNeil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Strack, AM; Fong, TM; Wyvratt, MJ; Nargund, RP Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity. Bioorg Med Chem Lett20:6524-32 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50329959 |
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| n/a |
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| Name | BDBM50329959 |
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| Synonyms: | (6-chloro-5-methyl-3-(2-(1-methyl-1H-1,2,4-triazol-5-yl)propan-2-yl)-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)((1R,2R)-2-(2,4-difluorophenyl)-4-(methyl(tetrahydro-2H-pyran-4-yl)amino)cyclopentyl)methanone | CHEMBL1269576 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H48ClF2N5O2 |
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| Mol. Mass. | 680.27 |
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| SMILES | CN(C1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCC2(C[C@@H](c3cc(C)c(Cl)cc23)C(C)(C)c2ncnn2C)CC1)C1CCOCC1 |r| |
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| Structure | 
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