| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
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| Ligand | BDBM50329966 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_676025 (CHEMBL1272963) |
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| IC50 | 5169±n/a nM |
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| Citation |  Powell, DA; Ramtohul, Y; Lebrun, ME; Oballa, R; Bhat, S; Falgueyret, JP; Guiral, S; Huang, Z; Skorey, K; Tawa, P; Zhang, L 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors. Bioorg Med Chem Lett20:6366-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA (8-3)-desaturase |
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| Name: | Acyl-CoA (8-3)-desaturase |
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| Synonyms: | FADS1_RAT | Fads1 | Fatty acid desaturase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52505.96 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_852948 |
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| Residue: | 447 |
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| Sequence: | MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSR
VISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRA
TVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPFTLCAVLLSTVQAQAGWL
QHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPL
FFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLA
WMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVS
TQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESK
PLLTAFADIVYSLKESGQLWLDAYLHQ
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| BDBM50329966 |
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| n/a |
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| Name | BDBM50329966 |
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| Synonyms: | 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzo[d]imidazole | CHEMBL1272304 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15FN2O2S |
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| Mol. Mass. | 366.409 |
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| SMILES | CS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)-c1ccccc1F |
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| Structure | 
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