Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase B-raf

Ligand

BDBM50026206

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_685663 (CHEMBL1285565)

IC50

<0.320000±n/a nM

Citation

Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem53:7874-8 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase B-raf

Name:

Serine/threonine-protein kinase B-raf

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

84446.00

Organism:

Homo sapiens (Human)

Description:

P15056

Residue:

766

Sequence:

MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

BDBM50026206

n/a

Name

BDBM50026206

Synonyms:

CHEMBL1276195

Type

Small organic molecule

Emp. Form.

C33H30F2N8

Mol. Mass.

576.6417

SMILES

[H][C@]12CN(c3cc(F)c(c(F)c3)-c3ccnc4c(c(nn34)-c3ccncc3)-c3cccc4[nH]ncc34)[C@]([H])(CN1CC(C)C)C2 |r,wU:36.42,1.0,(21.41,.41,;20.33,-.69,;20.34,-2.23,;19,-3.01,;19.01,-4.54,;17.67,-5.32,;17.69,-6.86,;16.35,-7.64,;19.02,-7.62,;20.35,-6.85,;21.69,-7.62,;20.35,-5.31,;19.03,-9.16,;17.7,-9.93,;17.7,-11.48,;19.03,-12.25,;20.37,-11.47,;21.84,-11.95,;22.75,-10.7,;21.84,-9.44,;20.36,-9.92,;24.29,-10.69,;25.06,-12.03,;26.6,-12.03,;27.37,-10.7,;26.59,-9.36,;25.06,-9.36,;22.32,-13.42,;23.82,-13.73,;24.3,-15.19,;23.27,-16.35,;21.76,-16.03,;20.51,-16.92,;19.27,-16.01,;19.75,-14.56,;21.29,-14.56,;17.67,-2.25,;16.12,-2.25,;17.66,-.71,;18.99,.07,;18.98,1.62,;20.31,2.39,;20.31,3.93,;21.65,1.63,;18.75,-1.15,)|

Structure