Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase B-raf

Ligand

BDBM50330918

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_685663 (CHEMBL1285565)

IC50

0.520000±n/a nM

Citation

Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem53:7874-8 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase B-raf

Name:

Serine/threonine-protein kinase B-raf

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

84446.00

Organism:

Homo sapiens (Human)

Description:

P15056

Residue:

766

Sequence:

MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

BDBM50330918

n/a

Name

BDBM50330918

Synonyms:

(1R,4R)-5-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-fluorobenzyl)-2-oxa-5-azabicyclo[2.2.1]heptane | CHEMBL1276190

Type

Small organic molecule

Emp. Form.

C30H24FN7O

Mol. Mass.

517.5563

SMILES

Fc1cc(CN2C[C@H]3C[C@@H]2CO3)ccc1-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |r,wD:9.8,7.7,(-13.19,-23.21,;-11.86,-22.44,;-11.88,-20.9,;-10.53,-20.12,;-10.54,-18.57,;-9.21,-17.8,;-7.88,-18.58,;-6.54,-17.83,;-7.7,-16.67,;-9.19,-16.26,;-7.86,-15.5,;-6.52,-16.28,;-9.19,-20.88,;-9.19,-22.42,;-10.52,-23.2,;-10.51,-24.73,;-11.85,-25.5,;-11.85,-27.05,;-10.51,-27.82,;-9.18,-27.05,;-7.7,-27.53,;-6.79,-26.27,;-7.7,-25.02,;-9.18,-25.5,;-5.25,-26.27,;-4.48,-27.61,;-2.94,-27.61,;-2.17,-26.27,;-2.95,-24.93,;-4.49,-24.94,;-7.23,-28.99,;-5.72,-29.31,;-5.24,-30.77,;-6.27,-31.92,;-7.78,-31.6,;-9.03,-32.5,;-10.27,-31.59,;-9.79,-30.13,;-8.25,-30.14,)|

Structure