Reaction Details |
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Target | Leucyl-cystinyl aminopeptidase |
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Ligand | BDBM50331035 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_684889 (CHEMBL1286213) |
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Ki | 9.3±n/a nM |
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Citation | Andersson, H; Demaegdt, H; Vauquelin, G; Lindeberg, G; Karlén, A; Hallberg, M; Erdélyi, M; Hallberg, A Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP). J Med Chem53:8059-71 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leucyl-cystinyl aminopeptidase |
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Name: | Leucyl-cystinyl aminopeptidase |
Synonyms: | Aminopeptidase | Aminopeptidase (P-LAP) | Cystinyl aminopeptidase | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | LCAP_HUMAN | LNPEP | Leucyl-cystinyl aminopeptidase, pregnancy serum form | OTASE | Oxytocinase | P-LAP | Placental leucine aminopeptidase |
Type: | PROTEIN |
Mol. Mass.: | 117334.10 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1473494 |
Residue: | 1025 |
Sequence: | MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWL
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BDBM50331035 |
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n/a |
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Name | BDBM50331035 |
Synonyms: | (S)-2-((S)-1-((S)-2-((2S,3S)-2-((S)-2-amino-3-methylbutanamido)-3-methylpentanamido)-3-(1H-imidazol-5-yl)propanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanoic acid | CHEMBL1275682 |
Type | Small organic molecule |
Emp. Form. | C31H45N7O6 |
Mol. Mass. | 611.7323 |
SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| |
Structure |
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