Ki Summary

Reaction Details

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Target

Potassium voltage-gated channel subfamily A member 5

Ligand

BDBM50331474

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_687189 (CHEMBL1291814)

IC50

340±n/a nM

Citation

Haffner, CD; Thomson, SA; Guo, Y; Petrov, K; Larkin, A; Banker, P; Schaaf, G; Dickerson, S; Gobel, J; Gillie, D; Condreay, JP; Poole, C; Carpenter, T; Ulrich, J Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2. Bioorg Med Chem Lett20:6989-92 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Potassium voltage-gated channel subfamily A member 5

Name:

Potassium voltage-gated channel subfamily A member 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

67222.47

Organism:

Homo sapiens (Human)

Description:

P22460

Residue:

613

Sequence:

MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL

BDBM50331474

n/a

Name

BDBM50331474

Synonyms:

CHEMBL1290618 | Pyrrole-1-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

Type

Small organic molecule

Emp. Form.

C23H23FN4O3S

Mol. Mass.

454.517

SMILES

CC(C)(CNC(=O)n1cccc1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15|

Structure