Reaction Details |
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Target | Stromelysin-1 |
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Ligand | BDBM50332283 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_686066 (CHEMBL1292822) |
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IC50 | 5800±n/a nM |
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Citation | Girijavallabhan, VM; Chen, L; Dai, C; Feltz, RJ; Firmansjah, L; Li, D; Kim, SH; Kozlowski, JA; Lavey, BJ; Kosinski, A; Piwinski, JJ; Popovici-Muller, J; Rizvi, R; Rosner, KE; Shankar, BB; Shih, NY; Siddiqui, MA; Tong, L; Wong, MK; Yang, DY; Yang, L; Yu, W; Zhou, G; Guo, Z; Orth, P; Madison, V; Bian, H; Lundell, D; Niu, X; Shah, H; Sun, J; Umland, S Novel TNF-a converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases. Bioorg Med Chem Lett20:7283-7 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Stromelysin-1 |
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Name: | Stromelysin-1 |
Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
Type: | Enzyme |
Mol. Mass.: | 53973.13 |
Organism: | Homo sapiens (Human) |
Description: | P08254 |
Residue: | 477 |
Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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BDBM50332283 |
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n/a |
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Name | BDBM50332283 |
Synonyms: | (R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(pyridin-3-ylethynyl)imidazolidine-2,4-dione | CHEMBL1287851 |
Type | Small organic molecule |
Emp. Form. | C20H16N4O4 |
Mol. Mass. | 376.3654 |
SMILES | COc1ccc2CN(C[C@]3(NC(=O)NC3=O)C#Cc3cccnc3)C(=O)c2c1 |r| |
Structure |
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