| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 1 |
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| Ligand | BDBM50332363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_694812 (CHEMBL1639759) |
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| EC50 | 17±n/a nM |
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| Citation |  Pinard, E; Alberati, D; Bender, M; Borroni, E; Brom, V; Burner, S; Fischer, H; Hainzl, D; Halm, R; Hauser, N; Jolidon, S; Lengyel, J; Marty, HP; Meyer, T; Moreau, JL; Mory, R; Narquizian, R; Norcross, RD; Schmid, P; Wermuth, R; Zimmerli, D Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors. Bioorg Med Chem Lett20:6960-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 1 |
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| Name: | Sodium- and chloride-dependent glycine transporter 1 |
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| Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
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| Type: | Enzyme |
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| Mol. Mass.: | 78270.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48067 |
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| Residue: | 706 |
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| Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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| BDBM50332363 |
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| n/a |
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| Name | BDBM50332363 |
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| Synonyms: | (S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(5-(pyridin-4-yl)isoindolin-2-yl)methanone | CHEMBL1631021 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21F3N2O4S |
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| Mol. Mass. | 490.495 |
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| SMILES | C[C@H](Oc1ccc(cc1C(=O)N1Cc2ccc(cc2C1)-c1ccncc1)S(C)(=O)=O)C(F)(F)F |r| |
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| Structure | 
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