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TargetCannabinoid receptor 1
LigandBDBM50332878
Substrate/Competitorn/a
Meas. Tech.ChEMBL_694005
Ki 290.1±n/a nM
Citation Silvestri RLigresti ALa Regina GPiscitelli FGatti VLavecchia ABrizzi APasquini SAllarà MFantini NCarai MABigogno CRozio MGSinisi RNovellino EColombo GDi Marzo VDondio GCorelli F Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands. Eur J Med Chem 45:5878-86 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50332878
n/a
NameBDBM50332878
Synonyms:1-(2,4-Dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-N-propyl-1H-pyrazole-3-carboxamide | CHEMBL1631166
TypeSmall organic molecule
Emp. Form.C20H22Cl2N4O
Mol. Mass.405.321
SMILESCCCNC(=O)c1nn(c(c1C)-n1c(C)ccc1C)-c1ccc(Cl)cc1Cl |(20.22,-4.85,;19.42,-3.51,;17.9,-3.54,;17.11,-2.21,;15.57,-2.24,;14.78,-.92,;14.83,-3.58,;15.31,-5.02,;14.08,-5.94,;12.83,-5.05,;13.29,-3.58,;12.38,-2.34,;11.37,-5.54,;10.9,-6.99,;11.8,-8.23,;9.35,-7,;8.87,-5.54,;10.09,-4.63,;10.08,-3.09,;14.1,-7.48,;12.77,-8.27,;12.79,-9.81,;14.13,-10.57,;14.14,-12.11,;15.46,-9.79,;15.44,-8.24,;16.77,-7.45,)|
Structure
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