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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucagon receptor | ||
| Ligand | BDBM50334486 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_701136 (CHEMBL1648234) | ||
| IC50 | 3.2±n/a nM | ||
| Citation |  Shen, DM; Brady, EJ; Candelore, MR; Dallas-Yang, Q; Ding, VD; Feeney, WP; Jiang, G; McCann, ME; Mock, S; Qureshi, SA; Saperstein, R; Shen, X; Tong, X; Tota, LM; Wright, MJ; Yang, X; Zheng, S; Chapman, KT; Zhang, BB; Tata, JR; Parmee, ER Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core. Bioorg Med Chem Lett21:76-81 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucagon receptor | |||
| Name: | Glucagon receptor | ||
| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 54026.92 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P47871 | ||
| Residue: | 477 | ||
| Sequence: |
| ||
| BDBM50334486 | |||
| n/a | |||
| Name | BDBM50334486 | ||
| Synonyms: | CHEMBL1643951 | trans-4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)-N-(2H-tetrazol-5-yl)benzamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H32F3N7O3 | ||
| Mol. Mass. | 559.5833 | ||
| SMILES | CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r,wU:7.10,wD:4.3,(26.38,-4.09,;27.72,-3.32,;29.05,-4.09,;27.7,-4.85,;27.72,-1.78,;29.05,-1.01,;29.05,.54,;27.72,1.29,;26.38,.53,;26.38,-1.01,;27.71,2.83,;26.38,3.6,;25.05,2.82,;25.05,1.27,;23.71,.5,;22.38,1.27,;22.38,2.82,;23.71,3.59,;21.05,.5,;21.04,-1.04,;19.71,1.27,;18.38,.5,;16.98,1.14,;15.95,-.01,;16.72,-1.34,;18.23,-1.02,;29.04,3.61,;29.04,5.15,;30.38,2.84,;31.71,3.62,;33.04,2.85,;34.37,3.62,;34.37,5.16,;35.7,5.94,;37.03,5.18,;38.36,5.96,;37.04,3.64,;38.36,4.41,;33.02,5.93,;31.7,5.15,)| | ||
| Structure | 
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