| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 22 |
|---|
| Ligand | BDBM50335881 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_715337 (CHEMBL1664624) |
|---|
| IC50 | 970±n/a nM |
|---|
| Citation |  Vang, T; Xie, Y; Liu, WH; Vidovic, D; Liu, Y; Wu, S; Smith, DH; Rinderspacher, A; Chung, C; Gong, G; Mustelin, T; Landry, DW; Rickert, RC; Schürer, SC; Deng, SX; Tautz, L Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids. J Med Chem54:562-71 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 22 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 22 |
|---|
| Synonyms: | 3.1.3.48 | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP | LyP | Lymphoid phosphatase | Lymphoid phosphatase (Lyp) | PEP | PEST-domain phosphatase | PTN22_HUMAN | PTPN22 | PTPN8 | Tyrosine-protein phosphatase non-receptor type 22 (LYP) | tyrosine-protein phosphatase non-receptor type 22 isoform 1 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 91712.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y2R2 |
|---|
| Residue: | 807 |
|---|
| Sequence: | MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY
KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS
ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI
DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK
HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE
ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL
LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC
FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW
PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES
AVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS
EPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIET
YSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNS
SSFLNFGFANRFSKPKGPRNPPPTWNI
|
|
|
|---|
| BDBM50335881 |
|---|
| n/a |
|---|
| Name | BDBM50335881 |
|---|
| Synonyms: | 3-(1-(4-(benzylamino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-2-para-tolylbenzofuran-5-carboxylic acid | CHEMBL1650904 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H26N4O5 |
|---|
| Mol. Mass. | 510.5405 |
|---|
| SMILES | Cc1ccc(cc1)-c1oc2cc(O)c(cc2c1-c1cn(CCCC(=O)NCc2ccccc2)nn1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
