Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50336094 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_718115 (CHEMBL1671568) |
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IC50 | 0.3±n/a nM |
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Citation | Isabel, E; Mellon, C; Boyd, MJ; Chauret, N; Deschênes, D; Desmarais, S; Falgueyret, JP; Gauthier, JY; Khougaz, K; Lau, CK; Léger, S; Levorse, DA; Li, CS; Massé, F; Percival, MD; Roy, B; Scheigetz, J; Thérien, M; Truong, VL; Wesolowski, G; Young, RN; Zamboni, R; Black, WC Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. Bioorg Med Chem Lett21:920-3 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50336094 |
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n/a |
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Name | BDBM50336094 |
Synonyms: | 1-(4'-((S)-1-((S)-1-(1-cyanocyclopropylamino)-4-fluoro-4-methyl-1-oxopentan-2-ylamino)-2,2-difluoroethyl)-2-fluorobiphenyl-4-yl)cyclopropanecarboxamide | CHEMBL1669441 |
Type | Small organic molecule |
Emp. Form. | C28H30F4N4O2 |
Mol. Mass. | 530.557 |
SMILES | CC(C)(F)C[C@H](N[C@H](C(F)F)c1ccc(cc1)-c1ccc(cc1F)C1(CC1)C(N)=O)C(=O)NC1(CC1)C#N |r| |
Structure |
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