| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50337157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_726319 (CHEMBL1687307) |
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| IC50 | 5741±n/a nM |
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| Citation |  Sweis, RF; Hunt, JA; Kallashi, F; Hammond, ML; Chen, Y; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Cumiskey, AM; Latham, M; Rosa, R; Peterson, L; Sparrow, CP; Wright, SD; Anderson, MS; Sinclair, PJ 2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy. Bioorg Med Chem Lett21:1890-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50337157 |
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| n/a |
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| Name | BDBM50337157 |
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| Synonyms: | 7-methyl-2-(4-(2-oxo-3-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)phenyl)benzo[d]oxazole-5-carbonitrile | CHEMBL1682752 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25F3N4O2 |
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| Mol. Mass. | 518.5296 |
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| SMILES | Cc1cc(cc2nc(oc12)-c1ccc(CC(=O)CN2CCN(CC2)c2ccc(cc2)C(F)(F)F)cc1)C#N |
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| Structure | 
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