| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase D1 |
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| Ligand | BDBM50337696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_728808 (CHEMBL1686343) |
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| IC50 | 60±n/a nM |
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| Citation |  Gamber, GG; Meredith, E; Zhu, Q; Yan, W; Rao, C; Capparelli, M; Burgis, R; Enyedy, I; Zhang, JH; Soldermann, N; Beattie, K; Rozhitskaya, O; Koch, KA; Pagratis, N; Hosagrahara, V; Vega, RB; McKinsey, TA; Monovich, L 3,5-diarylazoles as novel and selective inhibitors of protein kinase D. Bioorg Med Chem Lett21:1447-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase D1 |
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| Name: | Serine/threonine-protein kinase D1 |
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| Synonyms: | KPCD1_HUMAN | PKD | PKD1 | PRKCM | PRKD1 | Protein kinase C mu | Protein kinase C mu type | Protein kinase C mu type (PRKD1) | Protein kinase C, PKC; classical/novel | Protein kinase D | Protein kinase D (PRKD1) | Serine/threonine-protein kinase D1 (PKD1) | nPKC-D1 | nPKC-mu |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 101705.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_115529463 |
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| Residue: | 912 |
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| Sequence: | MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE
PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA
SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC
GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESF
IGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQ
CKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDM
EEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKS
STVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTS
ALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHAL
MPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGG
KHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVME
KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF
PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGT
FPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ
DYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEET
EMKALGERVSIL
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| BDBM50337696 |
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| n/a |
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| Name | BDBM50337696 |
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| Synonyms: | (R)-N-(1-cyanoethyl)-3-(5-(4-(4-methylpiperazin-1-yl)phenyl)isoxazol-3-yl)benzamide | CHEMBL1683431 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N5O2 |
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| Mol. Mass. | 415.4876 |
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| SMILES | C[C@@H](NC(=O)c1cccc(c1)-c1cc(on1)-c1ccc(cc1)N1CCN(C)CC1)C#N |r| |
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| Structure | 
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