Found 205 hits with Last Name = 'beattie' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324297
(4-(1-Piperazin-1-yl[2,6]naphthyridin-3-yl)pyridin-...)Show SMILES C1CN(CCN1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C22H26N6O/c1-6-25-21(26-18-3-11-29-12-4-18)14-16(1)20-13-17-15-24-5-2-19(17)22(27-20)28-9-7-23-8-10-28/h1-2,5-6,13-15,18,23H,3-4,7-12H2,(H,25,26) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324315
(CHEMBL1214998 | Cyclohexyl-[4-(1-piperazin-1-yl[2,...)Show SMILES C1CCC(CC1)Nc1cc(ccn1)-c1cc2cnccc2c(n1)N1CCNCC1 Show InChI InChI=1S/C23H28N6/c1-2-4-19(5-3-1)27-22-15-17(6-9-26-22)21-14-18-16-25-8-7-20(18)23(28-21)29-12-10-24-11-13-29/h6-9,14-16,19,24H,1-5,10-13H2,(H,26,27) | NCI pathway
Reactome pathway
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CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324315
(CHEMBL1214998 | Cyclohexyl-[4-(1-piperazin-1-yl[2,...)Show SMILES C1CCC(CC1)Nc1cc(ccn1)-c1cc2cnccc2c(n1)N1CCNCC1 Show InChI InChI=1S/C23H28N6/c1-2-4-19(5-3-1)27-22-15-17(6-9-26-22)21-14-18-16-25-8-7-20(18)23(28-21)29-12-10-24-11-13-29/h6-9,14-16,19,24H,1-5,10-13H2,(H,26,27) | NCI pathway
Reactome pathway
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CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324322
(4-(2-cyclohexylaminopyridin-4-yl)-6-(piperazin-1-y...)Show SMILES O=C1NCc2c1cc(nc2-c1ccnc(NC2CCCCC2)c1)N1CCNCC1 Show InChI InChI=1S/C22H28N6O/c29-22-17-13-20(28-10-8-23-9-11-28)27-21(18(17)14-25-22)15-6-7-24-19(12-15)26-16-4-2-1-3-5-16/h6-7,12-13,16,23H,1-5,8-11,14H2,(H,24,26)(H,25,29) | NCI pathway
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| Article
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324323
(2'-Cyclohexylamino-6-piperazin-1-yl[2,4']bipyridin...)Show SMILES NC(=O)c1cc(nc(c1)-c1ccnc(NC2CCCCC2)c1)N1CCNCC1 Show InChI InChI=1S/C21H28N6O/c22-21(28)16-12-18(26-20(14-16)27-10-8-23-9-11-27)15-6-7-24-19(13-15)25-17-4-2-1-3-5-17/h6-7,12-14,17,23H,1-5,8-11H2,(H2,22,28)(H,24,25) | NCI pathway
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CHEMBL
MCE
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324328
(2'-(2-Chlorophenylamino)-6-piperazin-1-yl[2,4']bip...)Show SMILES NC(=O)c1cc(nc(c1)-c1ccnc(Nc2ccccc2Cl)c1)N1CCNCC1 Show InChI InChI=1S/C21H21ClN6O/c22-16-3-1-2-4-17(16)26-19-12-14(5-6-25-19)18-11-15(21(23)29)13-20(27-18)28-9-7-24-8-10-28/h1-6,11-13,24H,7-10H2,(H2,23,29)(H,25,26) | NCI pathway
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PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324327
(2'-(1-Methyl-1H-pyrazol-3-ylamino)-6-piperazin-1-y...)Show SMILES Cn1ccc(Nc2cc(ccn2)-c2cc(cc(n2)N2CCNCC2)C(N)=O)n1 Show InChI InChI=1S/C19H22N8O/c1-26-7-3-16(25-26)24-17-11-13(2-4-22-17)15-10-14(19(20)28)12-18(23-15)27-8-5-21-6-9-27/h2-4,7,10-12,21H,5-6,8-9H2,1H3,(H2,20,28)(H,22,24,25) | NCI pathway
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324324
(2'-Phenylamino-6-piperazin-1-yl[2,4']bipyridinyl-4...)Show SMILES NC(=O)c1cc(nc(c1)-c1ccnc(Nc2ccccc2)c1)N1CCNCC1 Show InChI InChI=1S/C21H22N6O/c22-21(28)16-12-18(26-20(14-16)27-10-8-23-9-11-27)15-6-7-24-19(13-15)25-17-4-2-1-3-5-17/h1-7,12-14,23H,8-11H2,(H2,22,28)(H,24,25) | NCI pathway
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PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324326
(4'-tert-Butylcarbamoyl-2''-isopropylamino-3,4,5,6-...)Show SMILES CC(C)Nc1cc(ccn1)-c1cc(cc(n1)N1CCNCC1)C(N)=O Show InChI InChI=1S/C18H24N6O/c1-12(2)22-16-10-13(3-4-21-16)15-9-14(18(19)25)11-17(23-15)24-7-5-20-6-8-24/h3-4,9-12,20H,5-8H2,1-2H3,(H2,19,25)(H,21,22) | NCI pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324325
(6-Piperazin-1-yl-2'-(tetrahydropyran-4-ylamino)[2,...)Show SMILES NC(=O)c1cc(nc(c1)-c1ccnc(NC2CCOCC2)c1)N1CCNCC1 Show InChI InChI=1S/C20H26N6O2/c21-20(27)15-11-17(25-19(13-15)26-7-5-22-6-8-26)14-1-4-23-18(12-14)24-16-2-9-28-10-3-16/h1,4,11-13,16,22H,2-3,5-10H2,(H2,21,27)(H,23,24) | NCI pathway
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PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324314
(1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...)Show SMILES O=C(NCCN1CCCC1)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C30H39N7O2/c38-30(33-11-16-36-12-1-2-13-36)22-5-14-37(15-6-22)29-26-4-9-31-21-24(26)19-27(35-29)23-3-10-32-28(20-23)34-25-7-17-39-18-8-25/h3-4,9-10,19-22,25H,1-2,5-8,11-18H2,(H,32,34)(H,33,38) | NCI pathway
Reactome pathway
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PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324348
(6-(piperazin-1-yl)-4-(4H-pyrazol-4-yl)-N-(tetrahyd...)Show SMILES C1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCOCC2)c1)-c1cn[nH]c1 Show InChI InChI=1S/C22H27N7O/c1-4-24-21(27-19-2-9-30-10-3-19)12-16(1)20-11-17(18-14-25-26-15-18)13-22(28-20)29-7-5-23-6-8-29/h1,4,11-15,19,23H,2-3,5-10H2,(H,24,27)(H,25,26) | NCI pathway
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PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324298
(CHEMBL1215712 | {4-[1-(4-Isobutylpiperazin-1-yl)[2...)Show SMILES CC(C)CN1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C26H34N6O/c1-19(2)18-31-9-11-32(12-10-31)26-23-4-7-27-17-21(23)15-24(30-26)20-3-8-28-25(16-20)29-22-5-13-33-14-6-22/h3-4,7-8,15-17,19,22H,5-6,9-14,18H2,1-2H3,(H,28,29) | NCI pathway
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324296
(1-[3-(2-Cyclohexylaminopyridin-4-yl)[2,6]naphthyri...)Show SMILES NCC1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 Show InChI InChI=1S/C25H32N6/c26-16-18-8-12-31(13-9-18)25-22-7-10-27-17-20(22)14-23(30-25)19-6-11-28-24(15-19)29-21-4-2-1-3-5-21/h6-7,10-11,14-15,17-18,21H,1-5,8-9,12-13,16,26H2,(H,28,29) | NCI pathway
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PC cid
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UniChem
Similars
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324305
(CHEMBL1214711 | N-(2-(pyrrolidin-1-yl)ethyl)-1-(3-...)Show SMILES O=C(NC1CCNCC1)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 Show InChI InChI=1S/C30H39N7O/c38-30(35-25-7-12-31-13-8-25)21-10-16-37(17-11-21)29-26-9-14-32-20-23(26)18-27(36-29)22-6-15-33-28(19-22)34-24-4-2-1-3-5-24/h6,9,14-15,18-21,24-25,31H,1-5,7-8,10-13,16-17H2,(H,33,34)(H,35,38) | NCI pathway
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PC sid
UniChem
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324306
(1-[3-(2-Cyclohexylaminopyridin-4-yl)[2,6]naphthyri...)Show SMILES O=C(NCCN1CCCC1)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 Show InChI InChI=1S/C31H41N7O/c39-31(34-14-19-37-15-4-5-16-37)23-10-17-38(18-11-23)30-27-9-12-32-22-25(27)20-28(36-30)24-8-13-33-29(21-24)35-26-6-2-1-3-7-26/h8-9,12-13,20-23,26H,1-7,10-11,14-19H2,(H,33,35)(H,34,39) | NCI pathway
Reactome pathway
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UniChem
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324347
(CHEMBL1215153 | Isopropyl-[6-piperazin-1-yl-4-(1H-...)Show SMILES CC(C)Nc1cc(ccn1)-c1cc(cc(n1)N1CCNCC1)-c1cn[nH]c1 Show InChI InChI=1S/C20H25N7/c1-14(2)25-19-10-15(3-4-22-19)18-9-16(17-12-23-24-13-17)11-20(26-18)27-7-5-21-6-8-27/h3-4,9-14,21H,5-8H2,1-2H3,(H,22,25)(H,23,24) | NCI pathway
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Polycystin-2
(Homo sapiens (Human)) | BDBM50324346
(CHEMBL1215151 | Cyclohexyl-[6-piperazin-1-yl-4-(1H...)Show SMILES C1CCC(CC1)Nc1cc(ccn1)-c1cc(cc(n1)N1CCNCC1)-c1cn[nH]c1 Show InChI InChI=1S/C23H29N7/c1-2-4-20(5-3-1)28-22-13-17(6-7-25-22)21-12-18(19-15-26-27-16-19)14-23(29-21)30-10-8-24-9-11-30/h6-7,12-16,20,24H,1-5,8-11H2,(H,25,28)(H,26,27) | PDB
MMDB
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PC sid
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD2 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Polycystin-2
(Homo sapiens (Human)) | BDBM50324324
(2'-Phenylamino-6-piperazin-1-yl[2,4']bipyridinyl-4...)Show SMILES NC(=O)c1cc(nc(c1)-c1ccnc(Nc2ccccc2)c1)N1CCNCC1 Show InChI InChI=1S/C21H22N6O/c22-21(28)16-12-18(26-20(14-16)27-10-8-23-9-11-27)15-6-7-24-19(13-15)25-17-4-2-1-3-5-17/h1-7,12-14,23H,8-11H2,(H2,22,28)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD2 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324346
(CHEMBL1215151 | Cyclohexyl-[6-piperazin-1-yl-4-(1H...)Show SMILES C1CCC(CC1)Nc1cc(ccn1)-c1cc(cc(n1)N1CCNCC1)-c1cn[nH]c1 Show InChI InChI=1S/C23H29N7/c1-2-4-20(5-3-1)28-22-13-17(6-7-25-22)21-12-18(19-15-26-27-16-19)14-23(29-21)30-10-8-24-9-11-30/h6-7,12-16,20,24H,1-5,8-11H2,(H,25,28)(H,26,27) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324294
(CHEMBL1215643 | Cyclohexyl-{4-[1-(4-cyclopropylmet...)Show SMILES C(C1CC1)N1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 Show InChI InChI=1S/C27H34N6/c1-2-4-23(5-3-1)30-26-17-21(8-11-29-26)25-16-22-18-28-10-9-24(22)27(31-25)33-14-12-32(13-15-33)19-20-6-7-20/h8-11,16-18,20,23H,1-7,12-15,19H2,(H,29,30) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324292
(CHEMBL1215641 | Cyclohexyl-{4-[1-(4-methylpiperazi...)Show SMILES CN1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 Show InChI InChI=1S/C24H30N6/c1-29-11-13-30(14-12-29)24-21-8-9-25-17-19(21)15-22(28-24)18-7-10-26-23(16-18)27-20-5-3-2-4-6-20/h7-10,15-17,20H,2-6,11-14H2,1H3,(H,26,27) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Polycystin-2
(Homo sapiens (Human)) | BDBM50324347
(CHEMBL1215153 | Isopropyl-[6-piperazin-1-yl-4-(1H-...)Show SMILES CC(C)Nc1cc(ccn1)-c1cc(cc(n1)N1CCNCC1)-c1cn[nH]c1 Show InChI InChI=1S/C20H25N7/c1-14(2)25-19-10-15(3-4-22-19)18-9-16(17-12-23-24-13-17)11-20(26-18)27-7-5-21-6-8-27/h3-4,9-14,21H,5-8H2,1-2H3,(H,22,25)(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD2 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324312
(1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...)Show SMILES CC(C)CNC(=O)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C28H36N6O2/c1-19(2)17-31-28(35)20-5-11-34(12-6-20)27-24-4-9-29-18-22(24)15-25(33-27)21-3-10-30-26(16-21)32-23-7-13-36-14-8-23/h3-4,9-10,15-16,18-20,23H,5-8,11-14,17H2,1-2H3,(H,30,32)(H,31,35) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324335
(2'-Cyclohexylamino-6-((R)-pyrrolidin-3-ylamino)[2,...)Show SMILES NC(=O)c1cc(N[C@@H]2CCNC2)nc(c1)-c1ccnc(NC2CCCCC2)c1 |r| Show InChI InChI=1S/C21H28N6O/c22-21(28)15-10-18(27-20(12-15)26-17-7-8-23-13-17)14-6-9-24-19(11-14)25-16-4-2-1-3-5-16/h6,9-12,16-17,23H,1-5,7-8,13H2,(H2,22,28)(H,24,25)(H,26,27)/t17-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Polycystin-2
(Homo sapiens (Human)) | BDBM50324348
(6-(piperazin-1-yl)-4-(4H-pyrazol-4-yl)-N-(tetrahyd...)Show SMILES C1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCOCC2)c1)-c1cn[nH]c1 Show InChI InChI=1S/C22H27N7O/c1-4-24-21(27-19-2-9-30-10-3-19)12-16(1)20-11-17(18-14-25-26-15-18)13-22(28-20)29-7-5-23-6-8-29/h1,4,11-15,19,23H,2-3,5-10H2,(H,24,27)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD2 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324309
(1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...)Show SMILES NC(=O)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C24H28N6O2/c25-23(31)16-3-9-30(10-4-16)24-20-2-7-26-15-18(20)13-21(29-24)17-1-8-27-22(14-17)28-19-5-11-32-12-6-19/h1-2,7-8,13-16,19H,3-6,9-12H2,(H2,25,31)(H,27,28) | NCI pathway
Reactome pathway
KEGG
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324313
(1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...)Show SMILES OCCNC(=O)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C26H32N6O3/c33-12-9-29-26(34)18-3-10-32(11-4-18)25-22-2-7-27-17-20(22)15-23(31-25)19-1-8-28-24(16-19)30-21-5-13-35-14-6-21/h1-2,7-8,15-18,21,33H,3-6,9-14H2,(H,28,30)(H,29,34) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324304
(1-[3-(2-Cyclohexylaminopyridin-4-yl)[2,6]naphthyri...)Show SMILES CNC(=O)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 Show InChI InChI=1S/C26H32N6O/c1-27-26(33)18-9-13-32(14-10-18)25-22-8-11-28-17-20(22)15-23(31-25)19-7-12-29-24(16-19)30-21-5-3-2-4-6-21/h7-8,11-12,15-18,21H,2-6,9-10,13-14H2,1H3,(H,27,33)(H,29,30) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324291
(CHEMBL1215640 | Cyclohexyl-{4-[1-((cis-3,5-dimethy...)Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 |r| Show InChI InChI=1S/C25H32N6/c1-17-15-31(16-18(2)28-17)25-22-9-10-26-14-20(22)12-23(30-25)19-8-11-27-24(13-19)29-21-6-4-3-5-7-21/h8-14,17-18,21,28H,3-7,15-16H2,1-2H3,(H,27,29)/t17-,18+ | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324311
(1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...)Show SMILES CC(C)NC(=O)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C27H34N6O2/c1-18(2)30-27(34)19-5-11-33(12-6-19)26-23-4-9-28-17-21(23)15-24(32-26)20-3-10-29-25(16-20)31-22-7-13-35-14-8-22/h3-4,9-10,15-19,22H,5-8,11-14H2,1-2H3,(H,29,31)(H,30,34) | NCI pathway
Reactome pathway
KEGG
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PC sid
UniChem
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PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324310
(1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...)Show SMILES CCNC(=O)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C26H32N6O2/c1-2-28-26(33)18-5-11-32(12-6-18)25-22-4-9-27-17-20(22)15-23(31-25)19-3-10-29-24(16-19)30-21-7-13-34-14-8-21/h3-4,9-10,15-18,21H,2,5-8,11-14H2,1H3,(H,28,33)(H,29,30) | NCI pathway
Reactome pathway
KEGG
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PC sid
UniChem
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PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50337697
((R)-N-(1-cyanoethyl)-3-(5-(4-((isopropylamino)meth...)Show SMILES CC(C)NCc1ccc(cc1)-c1cc([nH]n1)-c1cccc(c1)C(=O)N[C@H](C)C#N |r| Show InChI InChI=1S/C23H25N5O/c1-15(2)25-14-17-7-9-18(10-8-17)21-12-22(28-27-21)19-5-4-6-20(11-19)23(29)26-16(3)13-24/h4-12,15-16,25H,14H2,1-3H3,(H,26,29)(H,27,28)/t16-/m1/s1 | NCI pathway
Reactome pathway
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PC sid
UniChem
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PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKD1 by TR-FRET assay |
Bioorg Med Chem Lett 21: 1447-51 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.014
BindingDB Entry DOI: 10.7270/Q2JM29WX |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM3033
(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12 Show InChI InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKCalpha by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324334
(CHEMBL1215152 | Cyclohexyl-[6-piperazin-1-yl-4-(2H...)Show SMILES C1CCC(CC1)Nc1cc(ccn1)-c1cc(cc(n1)N1CCNCC1)-c1cc[nH]n1 Show InChI InChI=1S/C23H29N7/c1-2-4-19(5-3-1)27-22-15-17(6-8-25-22)21-14-18(20-7-9-26-29-20)16-23(28-21)30-12-10-24-11-13-30/h6-9,14-16,19,24H,1-5,10-13H2,(H,25,27)(H,26,29) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324307
(CHEMBL1214786 | {1-[3-(2-Cyclohexylaminopyridin-4-...)Show SMILES OC1CCN(CC1)C(=O)C1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 Show InChI InChI=1S/C30H38N6O2/c37-25-10-16-36(17-11-25)30(38)21-8-14-35(15-9-21)29-26-7-12-31-20-23(26)18-27(34-29)22-6-13-32-28(19-22)33-24-4-2-1-3-5-24/h6-7,12-13,18-21,24-25,37H,1-5,8-11,14-17H2,(H,32,33) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324330
(2'-Ethylamino-6-piperazin-1-yl[2,4']bipyridinyl-4-...)Show InChI InChI=1S/C17H22N6O/c1-2-20-15-10-12(3-4-21-15)14-9-13(17(18)24)11-16(22-14)23-7-5-19-6-8-23/h3-4,9-11,19H,2,5-8H2,1H3,(H2,18,24)(H,20,21) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324308
(2-Amino-1-(4-{3-[2-(tetrahydropyran-4-ylamino)pyri...)Show SMILES NCC(=O)N1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCOCC2)c1 Show InChI InChI=1S/C24H29N7O2/c25-15-23(32)30-7-9-31(10-8-30)24-20-2-5-26-16-18(20)13-21(29-24)17-1-6-27-22(14-17)28-19-3-11-33-12-4-19/h1-2,5-6,13-14,16,19H,3-4,7-12,15,25H2,(H,27,28) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324332
(2'-Phenylamino-6-piperazin-1-yl[2,4']bipyridinyl-4...)Show SMILES N#Cc1cc(nc(c1)-c1ccnc(Nc2ccccc2)c1)N1CCNCC1 Show InChI InChI=1S/C21H20N6/c22-15-16-12-19(26-21(13-16)27-10-8-23-9-11-27)17-6-7-24-20(14-17)25-18-4-2-1-3-5-18/h1-7,12-14,23H,8-11H2,(H,24,25) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50337694
((R)-N-(1-cyanoethyl)-3-(5-(4-((tetrahydro-2H-pyran...)Show SMILES C[C@@H](NC(=O)c1cccc(c1)-c1cc(on1)-c1ccc(CNC2CCOCC2)cc1)C#N |r| Show InChI InChI=1S/C25H26N4O3/c1-17(15-26)28-25(30)21-4-2-3-20(13-21)23-14-24(32-29-23)19-7-5-18(6-8-19)16-27-22-9-11-31-12-10-22/h2-8,13-14,17,22,27H,9-12,16H2,1H3,(H,28,30)/t17-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKD1 by TR-FRET assay |
Bioorg Med Chem Lett 21: 1447-51 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.014
BindingDB Entry DOI: 10.7270/Q2JM29WX |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324293
(CHEMBL1215642 | Cyclohexyl-{4-[1-(4-isobutylpipera...)Show SMILES CC(C)CN1CCN(CC1)c1nc(cc2cnccc12)-c1ccnc(NC2CCCCC2)c1 Show InChI InChI=1S/C27H36N6/c1-20(2)19-32-12-14-33(15-13-32)27-24-9-10-28-18-22(24)16-25(31-27)21-8-11-29-26(17-21)30-23-6-4-3-5-7-23/h8-11,16-18,20,23H,3-7,12-15,19H2,1-2H3,(H,29,30) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5400-21 (2010)
Article DOI: 10.1021/jm100075z
BindingDB Entry DOI: 10.7270/Q2T153T9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324329
(2'-Cyclopentylamino-6-piperazin-1-yl[2,4']bipyridi...)Show SMILES NC(=O)c1cc(nc(c1)-c1ccnc(NC2CCCC2)c1)N1CCNCC1 Show InChI InChI=1S/C20H26N6O/c21-20(27)15-11-17(25-19(13-15)26-9-7-22-8-10-26)14-5-6-23-18(12-14)24-16-3-1-2-4-16/h5-6,11-13,16,22H,1-4,7-10H2,(H2,21,27)(H,23,24) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324337
(2'-Cyclohexylamino-6-((R)-3-methylpiperazin-1-yl)[...)Show SMILES C[C@@H]1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCCCC2)c1)C(N)=O |r| Show InChI InChI=1S/C22H30N6O/c1-15-14-28(10-9-24-15)21-13-17(22(23)29)11-19(27-21)16-7-8-25-20(12-16)26-18-5-3-2-4-6-18/h7-8,11-13,15,18,24H,2-6,9-10,14H2,1H3,(H2,23,29)(H,25,26)/t15-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Polycystin-2
(Homo sapiens (Human)) | BDBM50324327
(2'-(1-Methyl-1H-pyrazol-3-ylamino)-6-piperazin-1-y...)Show SMILES Cn1ccc(Nc2cc(ccn2)-c2cc(cc(n2)N2CCNCC2)C(N)=O)n1 Show InChI InChI=1S/C19H22N8O/c1-26-7-3-16(25-26)24-17-11-13(2-4-22-17)15-10-14(19(20)28)12-18(23-15)27-8-5-21-6-9-27/h2-4,7,10-12,21H,5-6,8-9H2,1H3,(H2,20,28)(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD2 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324333
(2'-(1-Methyl-1H-pyrazol-3-ylamino)-6-piperazin-1-y...)Show SMILES Cn1ccc(Nc2cc(ccn2)-c2cc(cc(n2)N2CCNCC2)C#N)n1 Show InChI InChI=1S/C19H20N8/c1-26-7-3-17(25-26)24-18-12-15(2-4-22-18)16-10-14(13-20)11-19(23-16)27-8-5-21-6-9-27/h2-4,7,10-12,21H,5-6,8-9H2,1H3,(H,22,24,25) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50324338
(2'-Cyclohexylamino-6-((S)-3-methylpiperazin-1-yl)[...)Show SMILES C[C@H]1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCCCC2)c1)C(N)=O |r| Show InChI InChI=1S/C22H30N6O/c1-15-14-28(10-9-24-15)21-13-17(22(23)29)11-19(27-21)16-7-8-25-20(12-16)26-18-5-3-2-4-6-18/h7-8,11-13,15,18,24H,2-6,9-10,14H2,1H3,(H2,23,29)(H,25,26)/t15-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD1 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Polycystin-2
(Homo sapiens (Human)) | BDBM50324326
(4'-tert-Butylcarbamoyl-2''-isopropylamino-3,4,5,6-...)Show SMILES CC(C)Nc1cc(ccn1)-c1cc(cc(n1)N1CCNCC1)C(N)=O Show InChI InChI=1S/C18H24N6O/c1-12(2)22-16-10-13(3-4-21-16)15-9-14(18(19)25)11-17(23-15)24-7-5-20-6-8-24/h3-4,9-12,20H,5-8H2,1-2H3,(H2,19,25)(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD2 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Polycystin-2
(Homo sapiens (Human)) | BDBM50324328
(2'-(2-Chlorophenylamino)-6-piperazin-1-yl[2,4']bip...)Show SMILES NC(=O)c1cc(nc(c1)-c1ccnc(Nc2ccccc2Cl)c1)N1CCNCC1 Show InChI InChI=1S/C21H21ClN6O/c22-16-3-1-2-4-17(16)26-19-12-14(5-6-25-19)18-11-15(21(23)29)13-20(27-18)28-9-7-24-8-10-28/h1-6,11-13,24H,7-10H2,(H2,23,29)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD2 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Polycystin-2
(Homo sapiens (Human)) | BDBM50324323
(2'-Cyclohexylamino-6-piperazin-1-yl[2,4']bipyridin...)Show SMILES NC(=O)c1cc(nc(c1)-c1ccnc(NC2CCCCC2)c1)N1CCNCC1 Show InChI InChI=1S/C21H28N6O/c22-21(28)16-12-18(26-20(14-16)27-10-8-23-9-11-27)15-6-7-24-19(13-15)25-17-4-2-1-3-5-17/h6-7,12-14,17,23H,1-5,8-11H2,(H2,22,28)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PKD2 by TR-FRET assay |
J Med Chem 53: 5422-38 (2010)
Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50337698
((R)-N-(1-cyanoethyl)-3-(5-(4-((isopropylamino)meth...)Show SMILES CC(C)NCc1ccc(cc1)-c1cc(no1)-c1cccc(c1)C(=O)N[C@H](C)C#N |r| Show InChI InChI=1S/C23H24N4O2/c1-15(2)25-14-17-7-9-18(10-8-17)22-12-21(27-29-22)19-5-4-6-20(11-19)23(28)26-16(3)13-24/h4-12,15-16,25H,14H2,1-3H3,(H,26,28)/t16-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human PKD1 by TR-FRET assay |
Bioorg Med Chem Lett 21: 1447-51 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.014
BindingDB Entry DOI: 10.7270/Q2JM29WX |
More data for this
Ligand-Target Pair | |
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