| Reaction Details |
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 | Report a problem with these data |
| Target | B-cell receptor CD22 |
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| Ligand | BDBM50338744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727025 (CHEMBL1686885) |
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| IC50 | 190±n/a nM |
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| Citation |  Abdu-Allah, HH; Watanabe, K; Completo, GC; Sadagopan, M; Hayashizaki, K; Takaku, C; Tamanaka, T; Takematsu, H; Kozutsumi, Y; Paulson, JC; Tsubata, T; Ando, H; Ishida, H; Kiso, M CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold. Bioorg Med Chem19:1966-71 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B-cell receptor CD22 |
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| Name: | B-cell receptor CD22 |
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| Synonyms: | B-lymphocyte cell adhesion molecule | BL-CAM | CD22_MOUSE | CD_antigen=CD22 | Cd22 | Lyb-8 | Sialic acid-binding Ig-like lectin 2 | Siglec-2 | Siglec2 | T-cell surface antigen Leu-14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96597.27 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_727025 |
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| Residue: | 862 |
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| Sequence: | MRVHYLWLLLILGHAASAQYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNI
LLFQNYEFDKATKKFKGTVLYNKAEPELYPPKQRRVTFLGNSIDNCTLKIHPIRANDSGN
LGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFEYDILLQW
FLEDSKITSVTPSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSEVLSE
RTVRLDVKYTPKLEIKVNPTEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQEL
EQEQQMSKLILHSVTKDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEE
GQSVELICESLASPSATNYTWYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHG
KIDQEAKLDVHYAPKAVTTVIQSFTPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVL
KPGVLRIQKVTWDSMPVSCAACNHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRV
LLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAW
NLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLR
LEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWG
MKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAIL
RFPESDMHNAGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSEL
VQFGAGKRPQAKEDVDYVTLKH
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| BDBM50338744 |
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| n/a |
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| Name | BDBM50338744 |
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| Synonyms: | (2R,4S,5R,6R)-2-(biphenyl-4-ylmethoxy)-6-((1R,2R)-1,2-dihydroxy-3-(2-(4'-hydroxybiphenyl-4-yl)acetamido)propyl)-4-hydroxy-5-(2-hydroxyacetamido)tetrahydro-2H-pyran-2-carboxylic acid | CHEMBL1684361 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H40N2O11 |
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| Mol. Mass. | 700.731 |
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| SMILES | OCC(=O)N[C@@H]1[C@@H](O)C[C@@](OCc2ccc(cc2)-c2ccccc2)(O[C@H]1[C@H](O)[C@H](O)CNC(=O)Cc1ccc(cc1)-c1ccc(O)cc1)C(O)=O |r| |
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| Structure | 
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