Reaction Details |
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Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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Ligand | BDBM50338974 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_727299 (CHEMBL1687393) |
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IC50 | 390±n/a nM |
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Citation | Pick, A; Müller, H; Mayer, R; Haenisch, B; Pajeva, IK; Weigt, M; Bönisch, H; Müller, CE; Wiese, M Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). Bioorg Med Chem19:2090-102 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
Mol. Mass.: | 72329.48 |
Organism: | Homo sapiens (Human) |
Description: | Q9UNQ0 |
Residue: | 655 |
Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
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BDBM50338974 |
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n/a |
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Name | BDBM50338974 |
Synonyms: | 2-(3,4-Dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one | 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one | 5-hydroxy-3,7,3,4-tetramethoxyflavone | CHEMBL77966 | NSC-61837 | quercetin tetramethyl ether | quercitin-3,7,3',4'-tetramethyl ether | retusin |
Type | Small organic molecule |
Emp. Form. | C19H18O7 |
Mol. Mass. | 358.342 |
SMILES | COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(OC)c1)c(OC)c2=O |
Structure |
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