| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50339978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_739992 (CHEMBL1763052) |
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| IC50 | 190±n/a nM |
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| Citation |  Skerlj, R; Bridger, G; Zhou, Y; Bourque, E; Langille, J; Di Fluri, M; Bogucki, D; Yang, W; Li, T; Wang, L; Nan, S; Baird, I; Metz, M; Darkes, M; Labrecque, J; Lau, G; Fricker, S; Huskens, D; Schols, D Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication. Bioorg Med Chem Lett21:2450-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50339978 |
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| n/a |
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| Name | BDBM50339978 |
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| Synonyms: | CHEMBL1762329 | N-(3-(4-((4-bromophenyl)(3-methylpyridin-2-yloxy)methyl)piperidin-1-yl)butyl)-3,5-dichloroisonicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31BrCl2N4O2 |
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| Mol. Mass. | 606.381 |
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| SMILES | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(CC1)C(Oc1ncccc1C)c1ccc(Br)cc1 |
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| Structure | 
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